Recent content by Jamie2003

For me hunger means ghrelin, mostly made in the stomach, the rumbling and cramps that say go eat. Food noise is your head chewing on the next meal even while you eat the one in front of you. Might sound like BS (fair), but my weight loss surgery removed the ghrelin-making part of my stomach and...

What you're describing with long-term weight regain is completely typical. Nearly everyone who sheds pounds through diet and exercise alone ends up putting it back on eventually. My take is that once the system governing appetite and weight regulation takes damage, it rarely fully bounces back...

Oh totally relate!! Only started 1mg recently and the scale's barely moved, just a handful of pounds. But I do notice feeling lighter overall.

Love this reply! Sounds exactly like my own path through weight watchers and my sema journey! We're basically the same story...lol

Got well over five years' worth of the third compound stashed in the freezer at my current weekly amount. Currently running a smaller total dose, hoping I won't need to go much higher, so I might end up stretching that supply out even further. Not bad considering I only started building this...

Really hoping I notice something even at 0.25mg, just want a mild appetite reduction at this point. Already down 120 pounds and looking to shed a few more to really lean out, but my hunger's been unusually strong lately. Counting on the fact that my body weight sits well under the typical person...

My whole approach was just stick with whatever's working. Never needed to go past 10mg and I'm down 125 pounds so far. Sat at 5mg for around six months of that.

The lyophilized storage question is the right one to nail down first before anything else. Keeping it powdered until reconstitution is the correct approach - the peptide is most stable in lyophilized form and reconstituted product has a shorter effective window. The temperature and light...

The vaping cessation side effect is one of the most remarkable and under-discussed things about these medications. The mechanism is the same as food noise - dopamine reward signaling gets quieted broadly. People quit habits they'd been trying to quit for years without really trying. It's a...

The compounding pharmacy dose math follows the same logic as the standard calculation - concentration per ml times volume drawn. The part that trips people up is when the pharmacy labels the vial by total mg in the vial rather than by concentration, which requires one extra conversion step. Once...

Freezer for the powder, fridge after reconstitution, and 60 days as the window post-reconstitution is a solid conservative protocol. The dark storage for the carrier liquid is right - UV exposure degrades both BAC water and the compound faster than temperature alone.

11 months in with Tirz at 12.5mg split EOD and Cag on the way for future consideration is exactly the progression the OP's result makes tempting. 215 to 144 with the standard dose increases is a strong outcome to see before deciding on the stack. At 11 months and 12.5mg, what's the current...

6 months at 1.7mg with meaningful loss only in the first 2 months is the classic stall pattern that makes the jump to 2.4 feel overdue in hindsight. Hesitation about moving up is what delays the most people who would benefit from it. The OP's 250 to 140 includes the dose adjustments that made it...

430 days and almost at goal is a real milestone - that last stretch closes fast.

Tirz and sema target different receptors - GIP for tirz, GLP-1 for both - so mixing is pharmacologically redundant and the dosing math gets messy.