GLP-1 Plateau - Anyone Else?

Gym_Strong4

Gym_Strong4

Active member
So, I was on Rybelsus 14mg for about 9 months for weight control because of obesity, high cholesterol and being insulin resistant. It was working great! I dropped around 30 pounds and then...bam. Plateau. Now, the pills don't seem to do anything, and I'm fixating on food all the time. I'm having trouble feeling full, even when I eat high-protein, high-fiber meals.

I asked my doc about switching to Wegovy or Ozempic, but my insurance won't cover them anymore. I feel stuck. I'm slowly regaining weight even though I'm at the gym for an hour doing strength training and another half hour doing cardio every day.

I'm feeling pretty hopeless. Has anyone else gone through something similar? Any ideas on how to deal with building up a tolerance to these meds?

Found this community plateau playbook useful when mine wouldn't budge
 
Sounds like it's time to get serious about tracking your calories. Use a food scale and measure everything. No more estimating.

It's also very likely that your body has developed a tolerance to the Rybelsus. The other option is just paying out of pocket for the meds - I think it's around $350.
 
I've been on Ozempic for over 5 years now, and honestly, I've gained more weight than I've lost. I'm on the highest dose, and I'm still hungry all the time. I get Ozempic because I'm diabetic, and it's fantastic for that. But for weight loss, not so much.
 
Whenever I see posts like this that don't mention calorie tracking, I wonder if you have all the information. That might be the answer to the regain.
 
Here's what helped me when Mounjaro stopped working:

* Intermittent fasting in the morning. Essential amino acids + caffeine keep me from getting hungry.
* Eating protein/fiber first at meals prevents blood sugar spikes that make you more hungry. It's slower digestion.
* Calorie counting. I average weight and calories for the week and compare to the previous week.
* When trying to lose and not losing when calories were right, know to keep going, it's a stall.

Going down a few doses for 6-8 weeks then back up a step at a time helps people keep losing weight after hitting max dose.
 
Will your insurance cover Mounjaro or Zepbound? I just switched from Ozempic to Mounjaro because Ozempic stopped suppressing my appetite. They're all effective at lowering blood sugar.
 
Compounding tirzepatide might be the way to go. Search online for companies that sell it for less than regular scripts. I've been on Zepbound through a compounding pharmacy online. It works on hunger hormones and metabolism. It still costs $300-$400 a month. I've lost over 50 pounds in the last year. I'm in maintenance now and injected a lower dose a few days ago, and I'm still having trouble eating much.
 
I have more difficulty maintaining or losing weight when I'm lifting weights or doing resistance training. My body seems to crave more energy. It's much easier when I only do cardio.
 
Check the Ozempic or Wegovy website for your country; they might have special pricing for people without insurance coverage.
 
LosingtheLabrador said:
Here's what helped me when Mounjaro stopped working:

* Intermittent fasting in the morning. Essential amino acids + caffeine keep me from getting hungry.
* Eating protein/fiber first at meals prevents blood sugar spikes that make you more hungry. It's slower digestion.
* Calorie counting. I average weight and calories for the week and compare to the previous week.
* When trying to lose and not losing when calories were right, know to keep going, it's a stall.
Click to expand...

Thanks, I am going to give IF a try!
 
I agree with PulseBTW445 - hormones can mess everything up. It might be worth looking into Zepbound, especially if you're in perimenopause. I've heard some people have much better luck with it than Ozempic. If you're battling food noise, Zepbound may help more too.
 
Some people are just slow responders to these meds. Don't get discouraged! Consistency is key. Are you accurately tracking your calories? What's your daily intake?
 
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