GLP-1 meds: non-responders?

Is it just me, or does that link want me to sign up for something to read the article? Is there another link maybe?
 
Actually, what the article *really* says is that one in ten people in a clinical trial were considered "non-responders". That does NOT mean they had zero response, just a smaller one. It's not the same as saying 1 in 10 *overall*.

This is the kind of thing that makes science reporting suspect. The people in the trials aren't just any random person. They meet criteria, and likely have tried to lose weight before, maybe with other medicines that didn't work. So the trial group may have a higher percentage of people who are harder to treat than the general population.

It's still interesting and has more links in the article, like the one about the retatrutide study. I just wish the science reporting was better.
 
The link didn't work for me either. I doubt it says much I don't already know, though. Some people just don't feel much or eat past it. I bet in the future we'll see that people overeat for different reasons. Most overeat for reasons the two receptors tirz treats work on, but a few overeat for other reasons that hitting another receptor will fix.
 
For some perspective, here are some plots from the retatrutide phase 2 data.

At the 1mg level you can see that a pretty good portion of people were still pretty close to the 0% line after nearly a year.



But I'd bet that with the 12mg group, there wasn't anyone who hadn't lost any real weight at week 48.



I'm guessing other GLP data would show the same thing at low vs high doses.

Like always, I wouldn't take a news article covering science seriously, unless you just want a simple (and incorrect) understanding.
 
Reta does nothing for me. Up to 10mg. And nothing on tirz. Used a combo and still no hunger decrease.

Here is something weird. I went on another peptide. Zero hunger.

Go figure.
 
Those graphs are interesting. I hadn't seen them. The higher end is interesting too. maybe 20% losing 15% or more on the 1mg. Some seem to really do great. At the high dose even the 'worst' lost like 5% and a small amount lost 10%.
 
One interesting thing is that a year on 1mg of Reta is kinda effective, with an average of 9% weight loss. Other GLPs aren't close at those low doses. If you are kinda overweight it's a solid choice. The other real plus is there are probably fewer effects at that dose. Best effects to sides ratio probably.
 
I started Reta at 2mg. Got up to 7.5 and had to stop because of the bad sides. Didn't lose a single pound.

So, not a non-responder exactly, but not working how it should. I sped up the dose increases too fast. I'm off it to let it clear, and back on at 2mg now. Going to follow the study dosing this time. Three weeks, and I'm up a few pounds.

Need bloodwork, but I'll wait 2 months first.

No sides yet. Didn't feel anything the first time until 5mg.

Also on other peptides. Even if it doesn't help me lose, it should help with the other sides.
 
The article opens with someone on another GLP for over a year and maybe lost a pound. I've been a low-responder myself. I got sick when I jumped to 5mg a week. I had to lower the dose to prevent the effect, splitting 2mg into separate injections each week. I slowly went up again at 0.5 mg every month. Zero lost for like 5 months. I got sick and I finally dropped like 5 pounds. Some people don't respond well, others respond great.
 
Someone said a while back they didn’t lose anything until they got to like 15mg of tirz.

I asked how they mixed it, and they didn't say. Could be off on the dose, or maybe they just respond low.

Lots of things follow a normal curve. It's not a shock that some won't respond much or at all, and some will have a big response. Or maybe they get sides easily. You can't know ahead of time so go slow.
 
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