Psoriasis & KPV/KLOW: Experiences?

O

Ozempic_OG_21

Well-known member
Hi everyone,

I've battled psoriasis my entire life. Since starting on tirz, my skin's improved, even though the RX cream wasn't cutting it anymore. I'm also dealing with inverse psoriasis and nail issues and am curious about KPV to manage them. KLOW sounds interesting, but insomnia is a no-go, as tirz already messes with my sleep. Has anyone tried TA1?

What are your thoughts? Have you used KPV topically or traditionally? I'm eager to hear about your experiences.
 
I've tried both KLOW and KPV via subq. KPV seemed to help with skin sensitivity, and irritation. KLOW was a bit better, except at the injection site where it caused extra irritation.
 
I started that KPV post I think. I still use KPV subQ for eczema flare-ups and to lessen skin sensitivity while on Reta. Reta makes my back so dang itchy! I literally just did a shot because I took Reta yesterday and the itching started. Can't really speak on psoriasis though.

As for other stories about immune uses, my mom's dog (Labrador) always had inflamed, scaly skin, and hair loss. The vet thinks it's an autoimmune issue related to poor breeding. We started giving Buddy 0.5mg of KPV subQ every other day. His skin's improved dramatically! Any sores healed super fast, and his fur growth is looking better. It's the only change we made. I'm a believer, and I hope it helps you too.
 
Thanks for sharing, Light_Life!

I developed adult-onset eczema around when menopause hit, HRT has helped somewhat. But I've heard KLOW and KPV are awesome for skin issues. I ordered KPV to see if it works on its own since I'm already on both Reta and tirz. I'd prefer something simple, for cost reasons if nothing else, before diving into blended peps.
Your experience convinced me to try the KPV. It might not do anything for me (N=1!), but I love how we can all share experiences and create our own research database on this forum.
 
I have psoriasis on my palms. I tried injecting 500mcg of KPV subcutaneously daily, but things got worse. The itching got unbearable, and the peeling and redness increased. So, after a week, I stopped. Then, I mixed KPV with my hand cream (2mg/2 grams of cream), but that didn't help either.

Only an infrared lamp every other day improved things. I used it for 3 minutes.
 
I've started mixing KPV with BPC 157 because I have all sorts of joint injuries. I still don't want to do a KLOW stack due to cost issues and I have allergies with nickel and cobalt and don't want to extend that to the copper component. No feedback on the BPC 157 yet, but I'm still using the KPV. My eczema is dyshidrotic, which might be different from what you have, so my results might not be typical. I hope it helps you though.
 
MeltMom said:
I am wondering, for those using peptides like Ipamorelin, do you all cycle them, or can they be taken all the time?
Click to expand...

I'm not cycling ipam. Just cruising at 200mcg three times a day. I sometimes forget to pack my peps when I'm traveling for work, so I miss doses occasionally.
 
Has anyone tried Melanotan II? I did a trial a few months ago. I started with 100mcg every day for the first few days, then bumped it up to 150mcg. I went to the tanning salon one day, and even though I got a wicked burn, I ended up with a really nice tan.
 
GLP-1's inflammatory reduction alone can meaningfully improve psoriasis - worth tracking separately before adding KPV so you know which variable is driving the improvement. KPV's relaxation effect is consistent with what others report, but the baseline matters.
 
The 50/10/10/10 breakdown explains why batches can feel inconsistent - small fill ratio variations shift which component dominates. For psoriasis, KPV is what most people notice on skin response.
 
The skin improvement on tirz before adding topicals tracks with the systemic inflammation reduction GLP-1 produces - it's consistent with what the community reports even without a labeled indication. KPV has separate anti-inflammatory evidence; the psoriasis overlap is the systemic inflammation component.
 
KPV handles the inflammation side and GHK-cu handles tissue repair - keeping both ongoing for a skin condition makes sense.
 
KPV alone after a Klow start is the pattern a lot of people land on - the anti-inflammatory effect is more targeted and the skin response tends to be cleaner once you're past the initial sensitization phase.
 
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