Oops - Tirz in the fridge, not freezer!

Pretty sure the peak side effects aren't actually 2-4 months in. For tirzepatide at least, the biggest spike is right at the start. Nausea and diarrhea clearly drop off over time. Vomiting's all over the map. Constipation though—that one's stuck with me. But if we're talking 'peak,' that's definitely the first dose, not months later.

Peptide dry powder in the fridge rather than the freezer degrades faster but not catastrophically - the standard estimate is 3-6 months at refrigerator temp for dry lyophilized powder versus 12-24 months frozen. If the powder has been refrigerated for over a year, effective content may be lower than labeled but unlikely to be zero. The reconstitute-one-at-a-time approach is the right call for anything where starting potency is uncertain.

Freezer is the conservative choice when the evidence is ambiguous - peptide integrity holds longer at lower temps, and pulling individual vials for reconstitution as needed is the right protocol either way.

The dedicated mini fridge is the most popular solution I see - keeps it at a consistent temp without the door opening and closing of a main fridge. Shelf in the main fridge works fine too if you're disciplined about which temperature zone it goes in. The freezer question depends on reconstituted vs lyophilized - lyophilized handles freezing fine, reconstituted you really want just cold.