Tirzepatide as a pill?

SparkleStacy_RX

SparkleStacy_RX

Well-known member
Seriously?!

I saw it on one of those compounding websites.

And they're charging the same price it seems as their injectable version.

Thoughts?
 
A quick search shows only a couple compounding pharmacies are selling it. I've never heard of those pharmacies.

Maybe check Reddit for reviews?
 
It'd be difficult to predict how much your body actually absorbs and it would likely be way less than a shot.

I wouldn't take it. I have no interest in what's currently available. There's too much reliable research and user data with the shots to change now.
 
Just because you can make it into a pill, doesn't mean it'll do anything. Some vendors will sell anything people want to buy whether it's safe or effective (like DNP). The oral version of semaglutide needed special drugs to help with absorption, and even then, only a small amount makes it through. Tirzepatide in pill form will break down super fast in the stomach, so it probably won't work at all. If you must take it orally, orfoglipron might be okay, but injectable tirzepatide is better and has fewer side effects.
 
I agree with Jess1988. Patient education is so important here. The lower price point is appealing, but people should know that oral semaglutide comes with very specific usage instructions for it to be effective.
 
Eddie04 said:
Patient education is so important here. The lower price point is appealing, but people should know that oral semaglutide comes with very specific usage instructions for it to be effective.
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That's a great point. It's probably geared toward people who don't like needles.
 
I saw someone on Reddit said they lost 5 lbs in the first 10 days of the Rybelsus but had really bad side effects. Nausea and throwing up a lot. Sounds awful!
 
Jules2006 said:
I saw someone on Reddit said they lost 5 lbs in the first 10 days of the Rybelsus but had really bad side effects. Nausea and throwing up a lot. Sounds awful!
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Yeah, that's not good. I'd rather stick with the shot and deal with manageable side effects. Rapid weight loss like that is usually water weight, not fat.
 
Someone on another forum said they felt much better on Zepbound than the Rybelsus. It's interesting how different GLP-1 formulations affect people differently.
 
Oral semaglutide is real (Rybelsus) but oral tirzepatide hasn't reached that stage - a compounding site selling oral tirz is worth verifying before purchase.
 
the oral delivery development is real and moving faster than most people expected - long-acting formulations that can survive GI degradation and still hit therapeutic blood levels are the technical challenge, and the approaches published so far are genuinely novel. whether injectable forms become obsolete on a 5 or 10 year timeline depends on how fast the oral versions actually reach patients at accessible pricing.
 
the European branded pen pricing at significantly lower levels than US out-of-pocket costs is one of the more striking cross-market comparisons in this space - Spain and other EU markets with reference pricing or earlier generic timelines have reached price points that the US market is nowhere near at equivalent doses. the oral formulation question is separate from the pricing question, but both reflect how fragmented the access landscape is for the same compound across different markets
 
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