Splitting Tirz Dose: Good or Bad?

Dose splitting for GI tolerance is a legitimate approach - 1.5mg twice weekly at 3mg total is a gentler load than 5mg at once. The reconstitution question is separate; the forum's pinned posts and the wiki have the clearest step-by-step material for new users.

The every-other-dose pattern of severe symptoms is the clearest indicator that weekly dosing isn't working as a format - splitting into twice-weekly at lower amounts smooths out the peak concentration that's triggering the vomiting.

splitting early is the move when the side effects show up at standard weekly dosing - the same weekly total in two smaller doses maintains the coverage without the peak that drives the GI response. the transition back to weekly usually works fine once the body has adapted at the split dose level

1mg through 3mg once weekly then splitting 4mg into Friday 2mg and Tuesday 2mg is exactly the kind of adjustment that makes the higher dose more manageable! First week on the split is the right time to see how the diarrhea compares. How has day 2 after each dose felt so far?