Didn't Feel Anything Right Away? Help!

T

Thin-Possible

Well-known member
I'm not feeling any different, except maybe a little stomach upset. I started at .5 two days ago. I was expecting to feel something, but nothing's changed.

Most people here say they felt something RIGHT AWAY.

I feel so discouraged.

Did anyone else only start feeling the effects later, like at 1mg, or after more time at .5? I'm almost obsessing about whether it's working, which makes me think about food even MORE!
 
Well... I felt a difference the very first day I injected. Maybe it was just in my head. It's been about three weeks now, and the .25mg doesn't seem to last as long. The first week it lasted almost a full week, then about 5 days, and now only 3-4 days, and I'm not feeling as full.

That's my experience. I have one more week at .25 before moving to .5mg.
 
It has only been a couple of days, @Thin-Possible, so don't get discouraged! Everyone reacts differently. I started at 0.25mg for 3 months and immediately felt a huge drop in appetite. But even though I was eating half of what I used to, I didn't lose weight until I went to 0.5. Then, I lost almost 40lbs since last fall.

I've read that some people need to get to 1mg before they see results. So, keep trying! If that doesn't work, maybe try tirzepitide (Mounjaro). The explanation is that it targets two GLP receptor sites instead of just one, making it more effective than Ozempic.
 
I felt the effects right away. I actually felt pretty bad and needed a prescription for anti-nausea meds. The side effects went away over time, but then my cravings started to come back, even though I was still thinking about food less. I switched to a different brand and lost another 20 pounds. I've kept it off on the same dose I started with.

I still have cravings sometimes, but it works much better than not being on it. I have to say no sometimes because if I eat too much junk, I feel terrible afterward. That never used to happen before. Don't give up yet! Try increasing the dose or changing brands.
 
i'm guessing whatever dose got me here is what's gonna keep me here. just did what should be my final bump to 9mg and i'm maybe six pounds away. gonna stop the other med though, i started it mostly to fight the fatigue from the tirzepatide, and by six months in i'm not sure i even need it anymore. honestly might've just been my brain being tired on low calories. but now that my motivation came back, i don't think stopping it will drag me down again.
 
@Thin-Possible, the checking thing is so true! Hardly anyone talks about it. You're focusing on food thoughts by trying to see if they're gone, which makes them stronger. It's not the medication, it's just how attention works. Two days on .5mg is also very early. Most people don't feel much at the starting dose. It's normal to feel discouraged, but it's too soon to worry.
 
I'm only 5 weeks in and I don't see any effects like less hunger or less food noise. I have a lot of stomach problems, gas, bloating, constant noises, diarrhea, nausea, and vomiting. I hope it gets better soon, but I don't know. I just went up to .5 last weekend and it made me really sick. I vomited for two days and I've had diarrhea for four days. I'm also feeling discouraged.
 
@RunLady, my doctor said that you can avoid a lot of the stomach side effects if you inject farther from your stomach, like in your thigh. I don't know if it's true, but I haven't had any side effects, and I inject in my thigh. I think it's safe since my doctor told me to do it, but let me know if anyone knows otherwise!
 
I agree with @RunBeer282 about the food thoughts. It's like when you try *not* to think about a pink elephant, you can *only* think about a pink elephant! Try distracting yourself when you catch yourself checking in on the food noise. A walk, a book, anything to shift your focus.
 
I'm finding that I get full so fast now. Like, I'll eat a normal portion and then feel super bloated and gross. It's a reminder that I don't need to eat as much anymore. I've started using smaller plates at home to help with portion control.
 
loose skin won't go away without surgery. but that's what a healthy adult body looks like. real talk - most of us who fought weight and shame should get therapy. helps you not fall for the next sketchy industry selling you insecurity.
 
Two days at 0.5mg and feeling nothing is the standard loading window experience - the 0.25mg and 0.5mg doses exist to build tolerance, not to produce the full effect. Most people don't notice meaningful appetite suppression until weeks 2-4, and the stomach upset in the first few days is actually the mechanism working rather than a sign it isn't. If you're expecting the food noise to go quiet, that shift is usually clearer around the second or third dose. The initial dose also works differently for different people - some feel it immediately, most don't, and neither outcome predicts long-term response.
 
Same experience here actually. Some days hunger is nonstop, other days I barely want to eat anything. It really does come and go in waves for me too.
 
Two days at 0.5mg is still in the loading window - most don't feel appetite suppression until weeks 2-4, and mild stomach upset in the first few days is the mechanism working normally.
 
Saw an old photo pop up and just broke down. Realized how much I've transformed, how much better I'm doing. Years of running on empty that I didn't even see at the time. Sharing here because only this group gets what that shift feels like.
 
Talk to your pharmacist, they can walk you through the markings on your pen and help you nail down exactly how much you need. Made a huge difference for me understanding my dosage once someone explained it properly.
 
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