Higher dose = more weight loss?

Sage_1999

Sage_1999

Well-known member
I've been using tirzepatide for about 4 months. I'm on 6 mg now, no issues. I've lost about 22 pounds, but I haven't lost anything this past month. I don't feel hungry, my portions are tiny, and I'm super active, burning tons of calories. I was wondering if a higher dosage would make me lose weight faster? Is there a correlation between the dosage and weight loss?
 
I'd probably bump up the dosage. The studies I read showed the higher the dose the more weight people tended to lose. If you start feeling sick, then slow down.
 
Higher doses generally lead to more weight loss, but remember that weight is only one measure of health. You could be gaining muscle while losing fat. Are you lifting weights and eating enough protein? If so, the scale might not be telling the whole story. Also, water retention can mess with the scale -- some people lose weight in phases with water weight masking fat loss.

I find it helpful to track other things like waist size. My weight hasn't changed much, but I've lost an inch around my waist.

Or, it could be time to up your dose!
 
The recommended ramp-up is 2.5mg and 5mg each for a month. I think 7.5mg is when it's considered therapeutic. If you've been on 6mg for a while, jumping to 7.5mg should be fine.
 
Are you a big anabolic steroids user?

Regular folks don't build muscle that fast. It takes a ton of effort to gain even a pound of muscle.
 
I'm on TRT dosages (my bloodwork is in the normal range). I have a lot of AAS, but I bought it as a precaution of the shortages. But being at the higher-end of the range helps, for sure.

I'm holding off on anything crazy until my body fat is around 10-12%.

My point is that you can lose fat without the scale moving because of water, lean body mass, etc.
 
Increasing the dose might restart your weight loss. But are you tracking anything besides the scale? You mentioned exercising. If you're building muscle, the scale might not budge. I remember this girl on Reddit who hadn't lost weight in two months but had lost four inches off her waist! She was working out hard. Something to think about.

If that's not the case, then yeah, titrate up. You're four months in and only at 6mg. Try 7.5mg and see if that's your sweet spot. Good luck!
 
I agree with @Terry_40. Maybe try some body measurements, or even just how your clothes fit. The scale isn't the only thing that matters.
 
Just a tip for those using the pens: there's almost always some medication left after you finish a pen. I always draw out any leftovers using a new needle. It's like getting a free dose! You can get a pack of 100 needles for cheap.
 
Thanks @Terry_40 and @Hank_2002! I will buy a measuring tape right now. Sometimes I get impatient and forget about non-scale victories. LOL. I'll also try the 7.5mg dose. I appreciate it!
 
VialStory said:
Just a tip for those using the pens: there's almost always some medication left after you finish a pen. I always draw out any leftovers using a new needle. It's like getting a free dose! You can get a pack of 100 needles for cheap.
Click to expand...

That's a great tip! I always wondered about that. I'm definitely doing that from now on.
 
My doctor upped my tirz dose to 15 mg yesterday, thinking the extra weight loss will help my low testosterone levels. Heavier weight can suppress test, so dropping more should help there.
 
When people mention splitting doses, they usually mean asking if 2.5mg twice weekly is better than 5mg once weekly - that does create higher peak levels. The talk about 'breaks' to reset receptors is just made-up stuff though. Study data backs weekly dosing, so I'd tell newcomers to stick with that unless they have real reasons to try something different.
 
as someone who spent years teaching fitness, i've seen firsthand how brutal it is to keep weight off once you drop it. the science gets pretty tangled, but folks on these meds will likely be on them for a decade or more. what nobody really knows yet is what ten-plus years of steady injections will actually do to us. will we need bigger and bigger doses and run into problems, or stay at something manageable? honestly excited to watch what unfolds over time as we all find out what our bodies can handle.
 
Weekly dosing might just be easier for people to stick with rather than better results. That study comparing daily vs weekly showed maybe 2% difference at week 52, which for most people won't be life-changing. Total comes down to what fits your life.
 
I had drawers full of clothes that no longer fit me. Bought a few XL tops as my go-to outfits when heading out somewhere. Most of those fit me now, though the denim still needs time. Added all those pounds over my first year-and-a-half in retirement. Those retirement-phase beers absolutely catch up with you.
 
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