Tirzepatide tummy troubles - Sema a better bet?

Bee_Loss

Bee_Loss

Well-known member
Hi all,

I'm having a really rough time with tirzepatide. After my second 5mg shot, I was so nauseous for like ten days straight. I ended up losing like, seven pounds in that time because I couldn't keep anything down. It was awful.

So now I'm thinking maybe this isn't the right med for me. Has anyone else had bad nausea on tirzepatide but done better on semaglutide? I know semaglutide is supposed to be worse for nausea, but I'm wondering if anyone had the opposite experience?
 
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Maybe try going back to 2.5mg, or even something in between. Semaglutide wasn't too bad for me; I just felt bloated and had some mild nausea sometimes. I only felt really sick on tirzepatide when I got to like 14mg. They're both good meds, though!
 
Started sema back in March and stayed on it for four months, then switched to my fourth tirzepatide injection. Same experience-felt different before the changes showed. Stay with it!
 
Sema was way worse for me. The nausea was unbearable. On Tirz, I had it at first, but my body got used to it. It was never as bad as Sema.

Also, ask your doc about ondansetron. It helped me a lot.
 
Yeah, I had a super bad time with nausea on tirzepatide, too – like, couldn't even function. I switched to semaglutide, and the side effects are way more manageable for me. I know everyone's different, but I didn't get nearly as much nausea. I got my prescription through an online clinic and they were really helpful with the change.
 
Bee_Loss said:
After my second 5mg shot, I was so nauseous for like ten days straight. I ended up losing like, seven pounds in that time because I couldn't keep anything down. It was awful.
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That sounds rough. Have you tried adjusting your diet at all? Sometimes, eating smaller, more frequent meals can help with the nausea.
 
I've heard some people switch from WeGovy to Zepbound since insurance might cover one but not the other. Apparently, Zepbound can feel stronger, so some take it less often. Just something to keep in mind if you're considering other options!
 
Hey @Bee_Loss, if you do switch, start at a *really* low dose of semaglutide, lower than you think you need. I've seen some folks say that even though they were on a higher dose of another GLP-1, sema still hit them harder at first.
 
Thanks, everyone, for the advice! I really appreciate it. I'm going to talk to my doctor about maybe trying a lower dose or potentially switching to semaglutide. I'll definitely keep the diet tips in mind, too, @Coach_B_Fit!
 
I'm taking about 17-18 mg weekly with good appetite reduction for 2 months now. I planned to increase toward 20-25 mg to reach my goal, but started stacking semaglutide 6 weeks ago. I'm at 1 mg sema now. The original plan was to reduce the tirzepatide as I went up on the sema, but honestly haven't needed to.
 
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