Tirz plateau - switch to reta?

Charlie1989 said:
Sharing my experience because I was worried about losing muscle. I've been increasing Reta while cutting back on Tirz. Every two weeks, I lower tirz by 1mg and increase Reta by 1mg. Still losing weight though.
Hope this helps.
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That is an interesting approach. Are you tracking your body composition to see if you are maintaining muscle while losing weight? I'd be interested to know the results.
 
I saw a post from someone who had gastric sleeve surgery and regained the weight. They're now on a low dose of semaglutide. It sounds like the sema is helping them with the 'food noise' aspect that the sleeve didn't address.
 
The glucagon receptor being the likely driver of blood sugar stability on Reta is plausible - glucagon normally raises blood sugar, but Reta's modulatory effect on glucagon signaling can smooth out the irregular spikes some people experience outside of clinical diabetes thresholds. If Tirz doesn't show the same stabilizing effect, it would support the glucagon mechanism hypothesis since Tirz doesn't have glucagon receptor activity. The experiment is worth running carefully.
 
If the stall is recent and you're near goal, finishing the tirz first is the lower-risk call - reta's wash-in time is 3-4 weeks regardless, so switching now doesn't buy speed.
 
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