Crazy appetite suppression?!

So, my journey started with weekly injections of semaglutide, then tirzepatide, and now I'm using a combo of tirz plus retatrutide. I'm almost at my target weight, so I'm trying to dial things back and using these peptides to try and keep my food habits in check. I've been on 2mg of tirz and 4mg of reta for the past couple of months, and I'm starting to think about lowering my dosages.

But over the last couple weeks, my appetite has just vanished! It feels like I'm taking way more than I should! Zero nausea or stomach issues, just a complete lack of wanting to eat. I practically have to force myself to have anything.

One thought I had is that I just mixed up a fresh vial of tirzepatide. Of course, now I'm not even sure if this started when I switched vials. Maybe the stuff in the old vial wasn't as strong, even though it seemed to be working fine. Or maybe this new vial is stronger than it's supposed to be.

I'm wondering if anyone else has ever had this happen to them while using GLP-1 meds? It's really weird.

Maybe the vial was overfilled and you got a bigger dose than you thought?

First, double-check your calculations. Even veterans sometimes make mistakes when calculating dilutions and doses. Use a peptide calculator website to check your math for both peptides. Could you have mixed up the vials? If you have a different batch of either peptide, try that. Usually, hunger comes back as you approach your goal weight, not the opposite. Since it's been two weeks, a virus is probably not the cause.

If you don't have another batch of tirz, you could try a lower dose. However, even if your dose was off by 100%, going from 2mg to 4mg of tirz per week while already on 4mg of reta might not make a noticeable difference. A 100% error in the reta dose (8mg instead of 4mg) would be much more obvious, but that's unlikely if you're using the same vial/batch/dilution.

At 5.5 years maintaining on half-mg for 2.5 years. Predictable manageable nausea wave plus 48-hour appetite drop so I modify meals for protein, fiber, fluids or end up blocked. Dose decreases hurt blood glucose control, increases don't help. Started 123kg, now 85kg, stable. Lifting serious weight, built muscle. Lipidema probably sets my floor. Good with this.

Thanks for the reply and suggestions! I agree with all of that. It is a new vial from a new lot. Right now everything is a possibility. My math *should* be correct if the labels are accurate. I use Excel, so my math is done, the only thing is I could have plugged in an incorrect number, but I've double-checked. There's also the possibility I made an error drawing into a syringe. Since I dose twice a week, I've had three doses. I am pretty sure something is off somewhere. I skipped my dose yesterday and plan on doing it again the day after tomorrow. This might remain a mystery, LOL.

It's possible the vial contains something different than what it says on the label. However, I think a mistake while checking is more probable, but looks like you've checked this thoroughly. The dose would have to be off by double or more, or it would have to be a different drug to cause such a strong effect. It's surprising this isn't more common, given that vendors aren't subject to the same scrutiny as pharmaceutical companies. Their primary motivators for quality control seem to be personal ethics and fear of negative reviews or busted lab tests, since they have little legal liability.

Was it a new vendor for you? Was the source well-known and established, with third-party test results available? If one vial is bad, the whole batch probably is. Using another vial from the same batch won't help.

There have been rare cases of mix-ups (such as retatrutide and semaglutide or tirzepatide being accidentally mixed together), and one case of someone ending up in a coma after injecting insulin from a vial labeled as semaglutide. However, the latter is questionable, as it's an isolated incident that could have been intentional.

Of course, it's also possible you're experiencing a rare physiological response.

The only way to be sure is to have the vial tested, but buying a new batch from a different source is probably cheaper and faster. It is going to be a glp drug. No other drugs have such clear effects on appetite.

Look closely at your COAs, they usually give the fill volume. It's not exact, but it can give you a clue. If your previous vial was underfilled and the newer one really has some extra in it, then that new vial could be really strong. Some vendors are known to overfill.

Since peptides aren't regulated, the vials aren't consistent, especially between manufacturers.

I've had something similar happen, but not with peptides, with Ozempic a while back. I was at a brunch with some friends and I could only eat a few bites of my food. It was kind of embarrassing. I felt like "that girl" who orders a full meal and then barely touches it. But honestly, who cares what others think? Your health is more important.

I saw a post on Reddit about feeling like "that girl" at brunch. The person said, "Why is nobody talking about how humiliating it is when your 'one meal a day' finally arrives… and you tap out after 5 bites?" It sounds like you might be on too high a dose, @Happy_Update. If you can barely eat, you might be losing muscle mass, which isn't ideal.

Thanks @Sage12. I'm thinking it might be dose related too. I'll try dialing it back and seeing if that helps. I don't want to lose muscle, I want to lose the spare tire! I'm going to split my next dose and see what happens.

I've found that timing the shot helps. I take my shot before bed on Sunday. That way, I can eat more on the weekends when the shot is wearing off. Might be something for you to try! I can eat about half of what I used to and take the rest home, easy.

Appetite suppression hit hard after bumping to 3 mg from 2.5 last week.

Even low dose 2.5mg can be rough. I took 1mg of something combined with 7.5mg tirz a couple weeks ago and I'm only just getting back to eating normal. Hope it gets better for you soon.

For me these intense pulls happen when I'm not eating enough, skipping meals, wrong food types, and/or my digestion tanks. Make sure you're having little balanced meals throughout, being proactive even with suppressed hunger. I used homemade shakes with cottage cheese base at first to get past extreme suppression.

Response varies that much between people. Compound and dose are the main drivers.

The tirz+reta combination produces suppression durable enough to persist through vacation eating - the triple agonist stack from Reta on top of dual GIP/GLP-1 is the mechanism. Tropical cruise cocktails and ice cream over several months and still holding is a real data point on where the ceiling sits when the stack is working. The appetite suppression here is qualitatively different from mono or dual agonist results for most people.

The slower pace at meals is what most people adjust to last - appetite disappears faster than eating speed does, and the full-after-two-chips experience means the social side of eating changes most. Hard to explain to anyone who hasn't felt it.

T2D_Warrior_Jim said:

I take my shot before bed on Sunday. That way, I can eat more on the weekends when the shot is wearing off.

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Smart. Using the tail end as buffer never occurred to me.