There was a trial testing a dose several times higher than the standard sema amount. The extra pounds shed were modest against how much rougher side effects became, though the overall effect landed near what a very large tirz dose gives. My hunch is regulators eventually clear stronger doses for severe obesity or weak responders, but that's probably years off, and likely never as aggressive as the upper tirz range already in use. What stood out from that research was no brand-new scary reactions, just amplified versions of the usual ones. Sema's still the only one with that kind of high-dose data behind it, and even pushed that far it trails a solid mid-range tirz dose. Doesn't confirm pushing the other two higher is safe, but it's a mildly comforting sign.
