Sudden Hunger on Tirz/Reta - what gives?

My lab rat is currently administering 7.5mg of tirz and 4mg of reta. (They also have some NAD+, Mots-c, and KLOW80 cycles going). Last night, they started experimenting with TESA.

Their weight loss has stalled this past week, with a slight increase on the scale. While that's not definitive, they were consistently losing around 1-3 pounds weekly for several months prior.

The main concern is a noticeable increase in hunger and a decrease in heart rate.

They've only been on reta and Tirz for approximately 5 months.

They feel like they're already at a decent dosage, but are wondering what might be causing sudden changes in results despite using the same vial. Their cycle isn't particularly close (about 2 weeks away).

Every few weeks, I get intense cravings for foods I normally avoid when trying to lose weight. I'm talking pizza, ice cream, burgers, all kinds of stuff I usually don't crave.

I gain 2-5 pounds, feel bloated, and worry that my meds have stopped working and everything's ruined.

Then my period starts, and everything goes back to normal. The weight comes off in a day or two, the cravings disappear, and I'm like, "Oh, right."

I know you said it's not your cycle yet, Shot-Ready, but our bodies are weird, especially female bodies. A week isn't long enough to panic.

Interesting! I've been on 12.5mg of tirz for 4 months. I tried going up to 15mg, but the side effects, like exhaustion, were too much. So, I've stuck with 12.5mg because it's been effective at controlling appetite. Now, I'm annoyed by a plateau because I want to lose another 8 pounds before a trip in March. This weekend, I started adding reta. I injected 1mg on Friday and haven't noticed much, except for slight nausea after meals (which is expected since it's only been a few days!). I injected another 1mg today to see what happens. I've been on tirz for over a year and sema for over a year before that, so I'm pretty sure playing with reta doses won't cause any major issues. But, I've noticed I'm kind of hungry this weekend, which isn't typical with just tirz. I'm post-menopausal and on HRT, so my monthly cycle isn't a factor in my hunger.

I'm wondering if I should try survo instead of reta and add that to the tirz. I really just want the boost for glucagon/fat burning. I'm hoping that if I can kickstart things for 6-8 weeks, I can go back to tirz after my trip since I really like it overall – no side effects and it works as expected.

Tesamorelin and similar ghrelin-releasing substances might interfere with GLP-1 signaling at high doses. So, Shot-Ready, your Tirz might not be working as well with them. Also, these hormones are known to increase water retention, so you may not experience both appetite suppression and body recomposition simultaneously.

Wow, we have a lot in common! I also started about 5 months ago. I'm taking 7mg of tirz and 4mg of reta, and I just ordered KLOW. I'm sorry to hear about your hunger, Shot-Ready. I'm never hungry, though I can always eat. I inject tirz on Friday mornings and reta on Monday mornings. Each week, I fast for 24 to 50+ hours, and my weight loss has been consistent.

Thanks for the input, Taylor37. I'll keep that in mind and experiment with the TESA dosage to see if that's the issue. It's possible the water retention is masking fat loss too.

I'm on week 6 of sema and I felt the same way! The first few weeks, I felt full all the time. Now, those cravings are coming back hard!

Morgan07 said:

But, I've noticed I'm kind of hungry this weekend, which isn't typical with just tirz.

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I wonder if I need to up my dose already?

For those of you experiencing increased hunger, especially around your cycle, it's worth remembering that hormonal fluctuations can have a big impact on these medications. Estrogen specifically can influence appetite, so drops in estrogen could lead to increased cravings.

Wes1981 said:

I'm on week 6 of sema and I felt the same way! The first few weeks, I felt full all the time. Now, those cravings are coming back hard! I wonder if I need to up my dose already?

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Wes1981, it might be worth talking to your provider! Don't increase the dose without guidance if you can help it.

I appreciate all the insights! I'll adjust my protocol and observe the changes. Hopefully, it's just a temporary blip.

It is true that some ghrelin substances may inhibit GLP-1 signaling, I think Taylor37 is on the right track. I'd recommend a full blood panel to examine hormone levels for a clearer picture.

The stall with a scale bump on that stack after consistent loss usually tracks to TESA shifting water and glycogen rather than actual fat gain - a week of data normalizes it. The hunger increase when adding TESA is consistent with its GH pulse effect, separate from Reta's appetite mechanism.