GLP-1s and inflammation?

GLP-1 has documented anti-inflammatory effects beyond weight loss. Joint symptoms improving out of proportion to the scale changes is a consistent pattern here.

GLP-1s reducing visceral fat cuts the inflammatory signaling at the source - people with hypermobility and joint issues often report less pain within a few months even when weight loss is moderate. The anti-inflammatory pathway is independent of the fat loss and runs earlier.

CRP and IL-6 are the measurable markers for systemic inflammation - a basic panel before starting and again at 3 months gives you objective data beyond the feel.