Tirz on top of Reta?

Xan_1994

Xan_1994

Active member
I'm cruising on 6mg of Reta right now, and things are going smoothly. I've bumped it up to 10mg before without any problems besides some minor skin irritation. Instead of increasing the dose, I was thinking about adding 2.5mg of tirz for its anti-inflammatory effects and to help control my appetite. I was planning on waiting until my trip, so I don't have to pack extra stuff. How quickly will I notice the appetite suppression from tirz, and does this sound like a good plan? Thanks!
 
I actually did the opposite. I supplemented my tirzepatide with reta – I always kept my tirz dose low, never going above 5mg. Adding 2.5mg of reta helped me lose the final 8 lbs to reach my goal weight, but I did experience a few instances of low blood sugar with the combination. My lowest glucose reading was around 45 mg/dL, with an average of 75-85 mg/dL while using both. Tirz is said to suppress appetite within 10-12 hours of injection, but I usually feel it within 3-4 hours. Also, keep in mind that tirz can increase the risk of dehydration and low blood pressure by reducing your sense of thirst.
 
When is your vacation, Xan_1994?

It takes about a day for 2.5mg of Tirz to hit its peak levels, but it might take a few days to really start feeling the appetite suppression. It's not super fast-acting, especially if you don't already have some built up in your system.

If you're planning on using it regularly, why not start now?

Cagri might be better as an 'as needed' appetite suppressant, but even then, it can take a good part of a day to kick in fully. I haven't personally used it though.
 
I went from Tirz to Reta without any transition period. Even though the appetite suppression wasn't as strong, I prefer letting glucagon do its job without diluting it with another GLP.
 
I actually use both, split into smaller doses. My appetite is basically non-existent. I still want to eat, and sometimes do, but it's easier to be selective about what and when I eat.
 
I'm leaving the week of February 12th. It's only a 5 day trip so I was thinking about starting the tirz right before I go. I tried cagri twice and felt awful both times – super tired, even at 0.25mg. It definitely killed my appetite, but I don't want to feel like that on vacation.
 
I've seen some users experiment with DSIP and Epithalon alongside Tirzepatide, specifically to help manage blood pressure.
HormoneHustle said:
Also, keep in mind that tirz can increase the risk of dehydration and low blood pressure by reducing your sense of thirst.
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It's an interesting approach, though I'd recommend consulting with a healthcare professional before trying it. Some studies suggest DSIP might help regulate the cardiovascular system.
 
Compound said:
If you're planning on using it regularly, why not start now?
Click to expand...

Good point! I might just do that. I was mostly concerned about potential side effects messing with my productivity at work. But I guess a low dose shouldn't be too bad. Thanks!
 
Side effects are always a gamble... For me, staying hydrated is key. If I slack on water, that's when I get the headaches and fatigue. Electrolytes help too.
 
Just throwing this out there, but some people on TRT report that HCG becomes less effective when they add nandrolone. Not directly related to tirz, but some hormones do play weird games with each other. Could be something to keep in mind if you're on other meds/supplements.
 
Aggressive dual-stack at a very low calorie level is a significant load. Results aside, that combination and that deficit level should have bloodwork running alongside it to catch anything early.
 
The mechanism overlap is the key issue - Reta already activates GLP-1, GIP, and glucagon receptors, so adding tirz mainly adds redundant GIP agonism. The net new contribution is limited to whatever the tirz-specific GIP selectivity adds, which is not well characterized. Most community reports of the combination describe additive appetite suppression but also additive nausea and GI load. Optimizing the Reta dose before adding another molecule is the cleaner path.
 
The data showing minimal separation between 8mg and 12mg Reta is an underappreciated finding - more isn't always more with these compounds. The fact that Tirz worked without sides for you while Reta brings the food cravings is a real receptor sensitivity difference, not just luck. Some people just respond to one mechanism much better.
 
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