Tirz arrived! When do I pin?

15mg tirz and a year supply of reta is a solid foundation for the transition. Starting at 1mg reta is the right call - cautious enough to see how it responds without going in too heavy. What timeline are you thinking for stepping down the tirz as the reta ramps up?

Cutting back to 7.5mg when adding 2mg Reta is exactly the cautious approach that makes sense on a new stack. The overlap at full doses of both is a lot to manage all at once. A week in at those adjusted levels is still very early - how is it feeling compared to tirz alone?

The 31g and 32g struggle with low vial volume is a common pen issue - resistance increases as the vial empties and thinner gauges have trouble with the last 0.2ml or so. A 29g needle as the backup for the last draw solves it across most pen types.