Down 140! After 2.5 yrs...

48 lbs and continued progress over 2 years is the patient version that holds rather than the fast version that reverses. 140 lbs in 2.5 years for the OP is what the long-game commitment looks like at the far end. Congrats on staying with it.

22.5 with no issues is a solid tolerance ceiling when the dose has been progressive. The peak window at 17 hours and the couple more days coming down is the timing to plan around for the worst of the side effects. Down 140 over 2.5 years is remarkable - the context on dose management shows the care that got you there.

140 lbs across 2.5 years is extraordinary - the patience required for something that long and the consistency through whatever was happening in your life along the way is genuinely impressive. One of the most real examples of showing up for yourself I've seen posted here.