B12 with your GLP-1? Anyone?

Started a B12 sublingual around month 2 because the fatigue was getting old. Energy stabilized within a week or so. Not sure if it was the B12 or just adapting, but I kept it going since the cost is minimal.

The Metformin-B12 interaction is one of the more well-established but under-monitored drug effects - the mechanism is reduced absorption in the terminal ileum from long-term use, and it's dose and duration dependent. Anyone on a GLP-1 plus Metformin combination should have B12 checked annually; the deficiency develops slowly enough that symptoms can be dismissed as other things for years.