Hit a plateau - anyone else?

4-5 years on 1mg without problems and then the gastritis and daily GI issues starting is a tough way to end something that was clearly working. The plateau and the medical stop landing at the same time is genuinely hard. Switching to something with a different mechanism makes sense if the GI issues are the main barrier.

2mg ozempic for 3 years working solidly and then stopping is the real-world tolerance experience that gets documented but not talked about enough. the 47 pounds and 5 back is still a net win before mounjaro picked things back up. how does the mounjaro appetite suppression compare to what ozempic was doing at its best?

6 months stuck at 1mg and then the 2mg dose breaking the plateau in 3 weeks is the sequence that shows up often enough to be the standard advice. The Easter dinner test - eating very little and getting full fast - is the clearest early signal that the new dose is working. For the OP at 2 years in, the dose question is worth revisiting before assuming the plateau is permanent.

T2D and plateauing at 2mg after 9 months is exactly where the Mounjaro option becomes worth revisiting. The GIP receptor angle is the thing that Ozempic doesn't cover and that's often what breaks the plateau. You gotta weigh whether holding at 2mg is still doing something metabolically for the T2D even if the scale isn't moving. What does the A1C look like compared to when you started?

That's exactly what happened here too. Started at the smallest amount and felt appetite suppression almost right away. Went from frequent binge eating to eating quite modestly, even less than during a period at a healthier weight. Held at that smallest amount for a few months but saw zero weight loss despite the habit changes. Eventually moved up a level and the weight started coming off fast, close to 30lbs over the following few months.

Got down to a good number but have plateaued since. Honestly, the plateau's probably tied to stopping a different medication and picking up a daily habit that's boosted appetite. Recently quit that habit, and the doctor agreed to bump the dose up further. A few more doses at the current amount before that happens. Hoping to shed a bit more before maybe scaling back down for maintenance.

Right off the bat, 57 pounds gone is huge, and doing that at 70 while managing knee problems that limit how much you can move makes it that much more impressive. Nothing about your route here was the easy way. Staying this deliberate and intentional for two straight years counts for a lot.

On what you asked, going off what I've noticed from folks running this long-term:

1) Stalling out somewhere in that year-and-a-half to two-year window happens to almost everyone. Your system has caught up and adjusted. The part where hunger just disappeared without effort in the beginning fades over time, not gone completely, but noticeably less than before. That's not a sign the drug quit working, just that your body settled into a fresh balance. A lot of people bring up adjusting dose or layering in a second medication when they talk to their prescriber about this. Might be a conversation worth having.

2) About the cravings, given they show up occasionally rather than nonstop but land hard when they do, that reads more like specific triggers than a baseline hunger problem. A handful of things people in your position report finding useful:

* Working protein into each meal, doesn't take much, just needs to be regular

* Not letting hunger build too far unchecked (weirdly, grabbing something small right before a craving typically peaks can head off overeating)

* Some people say the pattern lines up with the weekly dosing cycle, roughest around day five or six when the medication's tapering off

One other point worth raising

The jump from 1mg up to 2mg wrecked me, constant vomiting and nausea. I went down to 1.25mg and stayed a few weeks, then edged up to 1.5 and 1.75, and after around 8 weeks of that I tried 2.0 again. Still unpleasant but bearable, and seeing my weight finally drop after such a long plateau made it worth it.

Ozempic/Wegovy took off 50 for me across 24 months. A move to Mounjaro brought 15 more off. Have you hit your max dose yet? Also, compounded versions might be weaker than the genuine product. I buy through the manufacturer's direct program.