Reta, BPC, and Tesa – anyone tried this combo?

Hong Kong Yanpep International
Interesting, Toni1991. I've been experimenting with DSIP, Epithalon, and Tirzepatide to see if they will lower my blood pressure. I'm 50, super low body fat, and I've been on TRT for a long time. After losing a bunch of weight, my BP was still kinda high, like 120/80, even after my doc lowered my BP meds. Then mercury exposure spiked my BP to 158/102. Doubling the meds didn't even work. I started the peptides and that dropped me to 130s/80s.
 
is the goal to find a dose that quiets food noise with basically no side effects? so if you're there, do you stay or slowly ramp up hoping it stays that way?
 
Seven is a decent reta baseline. Stacking with tirz makes sense if you want more suppression on both fronts - some folks find they get their best results that way. What dose makes sense depends on where you're at now, but you could start low and see if adding it gives you what you're after.
 
These aren't fat burners. They won't melt fat or rev your metabolism. What they do: quiet the food noise, make you feel full quicker, keep you satisfied longer. They make diets bearable and sustainable. This stuff will help you stick to a real plan. But it won't replace diet and moving more—you still gotta do the work on calories and activity.
 
I hear you on wanting to experiment. Personally, I haven't jumped into stacking yet because I'm still figuring out how tirz affects my appetite on its own. The food suppression is inconsistent for me too, and adding more variables sounds risky right now. If I had to pick one to try first, I'd probably go reta for the glucagon angle - but honestly, talk to your doc before mixing anything.
 
Stacking multiple compounds is tempting when you're feeling good but sometimes the cleanest approach is letting one cycle finish before adding the next layer. That way you actually know what's working and what might be causing issues if something shifts. How's the food noise at your current stack?
 
Four weeks on tirz then jumping to reta is a solid progression if you're comfortable with the jump. The KLOW cycle finishing first before you add the peptide stack makes sense - one variable at a time means you know what's actually affecting you. Smart play waiting rather than throwing everything in at once.
 
Tesa storage debate is real. Standard is fridge post-reconstitution, use within 4-6 weeks. The not-refrigerating theory isn't well-documented yet. For a first combo, standard storage seems like the right call until more data lands.
 
One dose of tesamorelin affecting glucose significantly is unlikely at standard doses - the GH pulse it generates is much shorter and milder than continuous GH elevation. The reta-plus-tesa combination for glucose over the longer term should actually trend the other direction as the insulin sensitization effect accumulates.
 
the rotation pattern for multiple daily and weekly compounds is the piece that takes the most planning - front-loading the nightly belly pinning to both sides and alternating keeps any one spot from accumulating too much tissue response, especially when BPC and TB are going in most nights. Reta once weekly in the gut gives it a dedicated site separate from the daily traffic
 
Okay, ready to start tesamorelin tonight. Already running reta plus cagri. Also dealing with a shredded meniscus and knee osteoarthritis. Read a lot about tesamorelin bringing on ache from water retention in the early weeks, first few weeks typically. Also read wonderful things about sleep improving, and I desperately need that.

Searched the forum and couldn't find much on this, might just be missing it. Would you mind sharing what your experience was like: was there noticeable swelling or discomfort in the joints, and roughly how long before it settled down?

Starting at half a milligram to see what happens. If I'm back here tomorrow complaining, feel free to say I told you so!
 
So next step's shifting to either the 3mg or the 4mg strength of Retatrutide, running that for a full month. Went with the lower option to keep things tolerable.

Visceral fat was genuinely the slowest to budge, took ages, and I had a lot stored there! Good news though, Reta really does excel at burning through it.

Tesamorelin's thought to potentially overstimulate the pituitary gland with continuous daily dosing, possibly leading to the drug losing effectiveness over time. Taking a couple days off periodically supposedly lets the receptors reset and stay sensitive, so the pituitary keeps responding with a strong natural growth hormone pulse whenever Tesa resumes.

Also helps keep IGF-1 lab readings within reasonable range.

Today marks another milestone too, just two pounds shy of my target weight now!!!!
 
Big fan of the growth-hormone releasing peptide personally. Currently running it and expect it'll stay part of my routine going forward. I'll probably always lean toward it over the older-generation option.

That said, I wouldn't dismiss the older one entirely either.

As mentioned already, the newer peptide was specifically studied for cutting visceral fat in people dealing with HIV-related fat redistribution. On average those patients carried far more visceral fat than the typical person just chasing body composition improvements.

I don't think there's an equivalent study for the older compound, so calling it a truly fair side-by-side feels premature. Especially once people start stacking it with a second releasing peptide.

Personally I wouldn't be shocked if results ended up fairly comparable long term, though that would hinge on the person, what they eat, how they train, how consistent the dosing is, where they started body-fat-wise, and so on.
 
Update after 5 weeks of tesamorelin at 1mg. I went from 5 on 2 off to daily these past 3 weeks and I'm running reta alongside, bumped up to 6mg last week after sitting on 5mg. I'm a 69 year old guy at 170 lbs with 10 to 15 lbs left to lose, training hard three times weekly right up to failure, with strength going up roughly 2% each week. Scale began dropping once more last week following a month-long stall. Bloodwork came back today with an IGF-1 of 355, z score 2.7, oops. No side effects, but I'm going back to weekday-only tesa and will retest in a month. Total testosterone is 764 with 98 free, well above last year's, when I was 30 lbs heavier. I pin tesa right after I wake, then have coffee right away, and I don't buy the idea that caffeine cortisol blunts it.
 
Tesa tends to go into stacks way too soon, and no offense, you're one of them. It's a peptide I'd add once leanness is already extreme and belly fat stays put. My goal is 10% body fat, and should abs still be hidden by then, Tesa gets considered. IMO there's no point starting it above 10-12% bf....
 
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