Transition from 15mg Tirz to Tirz+Reta dosage questions for obese male

Male, 34, five ten. Struggled with weight my whole life due to poor nutritional guidance early on, raised on low fat messaging from age three so my diet leaned almost entirely on sugar until my twenties. Topped out near 155 kilos back in late 2019. Began this year at 136 kilos, now down to 110, targeting 90 by year end. Running 15mg weekly of tirz currently and food noise still lingers. Recently shifted to carnivore since that helped quiet cravings before, planning to stay carnivore until dropping below 100 kilos then pivot into a calorie deficit. Just picked up reta to layer in, unsure how much to pull back tirz. Plan is two weekly injections, one compound per day. Considering a moderate tirz dose alongside a small reta amount for a month, then adjusting the ratio further each month after, eventually settling lower on tirz with more reta through the rest of the journey. Anyone with experience or thoughts on this setup? Also have a copper peptide arriving soon, planning daily use.

Not on the same day, no. And yes, there's a real benefit to it. I came across research showing official labs are exploring combination analogs, plus read through experiences from people running both together, then dug into it more myself. What really sold me on trying it was a paper covering how differently tirz and reta bind to the GLP-1 receptor, they end up complementing each other, at least that's been my experience. My blood sugar control has improved, and I've shed a solid amount of visceral fat too.

You've been running a pretty aggressive calorie deficit, so your body's fighting hard to pull food back in. Ever thought about trying the combined cagri-sema option? Should offer strong appetite control. Another route worth considering, go back to your previous tirz amount and slowly layer reta on top.

Or swing the other way entirely and go starch-heavy instead.

Either way, reta's my favorite. Best performer for weight loss even looking at two-year data. Tirz paired with elora might eventually beat it out in trials, but who knows.

Personally I'd ease into reta as a standalone treatment over time, running it alongside tirz in the transition period the way you described. Then layer in cagri or elora on top of reta if extra help's needed once you're past 8mg.

Same plan here. After losing over 120 lbs in a year on Tirz with a max of 5mg, I want to combine both to cut some visceral fat using Reta. The idea: drop Tirz to 4.5mg from 5mg and begin Reta with 0.5mg. Is it fine to inject them together, or should Tirz go Saturday and Reta Sunday? My concern is GLP1s hit me unusually hard. Prior to treatment I had tachycardia with a resting HR that stayed above 90-100. A year on Tirz brought it to 50-55 bpm. So I'm a bit afraid that starting Reta will bring the tachycardia back. What's the best starter dose for minimum risk of a heart rate increase with Reta? Reta is purely meant to clear my remaining visceral fat depot.

Four months on Tirz have brought a steady 1.5 lbs weekly, slow but healthy. I began adding Reta to see if the number would drop faster, and mostly it's going well. Here's my plan: weeks 1-2 at 1mg (a get-to-know-my-body stage), weeks 3-6 at 2mg (the actual start, part 2), weeks 7-10 at 4mg, then add 2mg monthly until I hit maintenance.

I'm stacking tirz with reta right now. I began on tirz, reached 15mg and was losing, but reta's long term metabolism and fat burning benefits intrigued me, I added reta at .5 mg. Now I'm at 2mg reta and 12mg tirz. I plan to keep raising reta to at least 4mg while cutting tirz to the minimum that still controls appetite. I wear a CGM so I don't go hypoglycemic.

Reta began at 2mg, then rose by 1mg each fortnight until 10mg. That's where I've held for some time, with 5mg Tirz weekly layered on top.

Male, 46, 5'11. Starting and highest weight 238lbs in October 2025, now 185lbs in April 2026. First Tirz shot in October 2025, reached 10mg, then five weeks ago started moving to Reta. Now taking 8mg Reta plus 5mg Tirz, spaced three days apart.

whats your actual breakdown between the two? i climbed to 15mg tirz then switched over to reta, currently at 5mg, and added 5mg of tirz again just recently since the hunger wasnt going away. hasnt made much difference honestly, still starving most of the time. not sure whether to dial reta up, tirz up, or just accept reta isnt right for me.

gotta be honest, almost everyone saying that hasnt actually dealt with severe long term obesity. ive seen a handful of people with more serious weight problems do great and lose 20 to 30 percent while running small amounts of either medication, but thats pretty rare. for someone just moderately overweight a small reta amount tends to work well. but holding onto a 56 percent loss like i am, i wish going higher on my dose were an option, except my skin starts actually hurting instead of just feeling a little off, and thats already on tirz 15 plus reta 8mg.

gonna bullet this out too since the full story would be an essay. / / 54 year old guy, 6'1, started at 330lbs. began tirzepatide december 2025, stuck with it seven months, two months at 2.5mg then five at 5mg. moved over to reta after that, began at 2mg and climbed to 5mg fast, planning to hold there a while. now considering stacking reta with tirz. hit some stalls, a month of travel didn't help and i haven't been exercising, but a 24 hour gym membership starts soon, maybe tonight. sitting at 270 now, 60 down from start, aiming for 199 eventually. not a quick process but the most success i've ever had losing weight. expect to stay on some low dose of this stuff indefinitely. these meds have genuinely turned things around for me and i'm grateful.