Reta - Week 2 thoughts?

Yes, absolutely possible, and likely wise, to scale back the dose! Just stay on top of hydration, and check back next week with whatever gets decided.

Usually give something a bottle or two, depending on daily amounts, before deciding if it's worth continuing. Tried a full ss31 run once, wasn't impressed.

As for reta, 2mg hit like a truck initially, and the effect's shifted over time, especially now training harder. Appetite suppression feels weaker lately but the near-total absence of food noise remains, plus fullness kicks in faster. Weekly Monday shots mean by Saturday the effects noticeably fade. Titrating to 4mg brought serious constipation, genuinely rough. Down 43 pounds but stalled recently.

Meanwhile a family member barely eats, zero noticeable sides. More dose for them doesn't add more side effects either, just steady loss, no constipation.

Short version, give it a real chance before writing it off.

Amazing!!

Just getting started here, hoping to hold steady around 2.5 ml! Appetite feels completely different compared to four days ago, aiming to drop weight while also building some muscle through the gym. Really appreciate the kind words here!

Bravo!

That reads as a genuinely lean athletic build already, and reta tends to suit that crowd well. Would expect saturation within a couple months given the timeline, so genuinely puzzled given the calorie deficit too... not thrilled with how reta's performed either. Adding it to tirz only brought another six pounds, and that was a while back. Pushed cardio up a bit, tried circuit training at the gym several times weekly. Nothing. Cut out the nightly drinks on weekdays. Nothing. Out of sheer frustration bumped tirz up a few days after the reta dose and only lost a couple pounds after weeks of nothing. Personally think there's just no real evidence anything keeps working indefinitely, and at some point the body just stops responding the same way.

Coming into this late, but I'm six months in. Started at 2mg for a month, no issues there, then increased 2.5mg every four weeks.

Now running 7.5mg every five days, and things picked back up after a month stuck at that same amount on a seven-day cycle.

Down 35 pounds and my waistline dropped four sizes, from a 38 down to a 34. Doing great at the gym too, my lifts have climbed steadily this whole stretch on Reta. Currently at 254, my lightest in five years, though even back then I wore a 36 waist. Body recomposition feels noticeably better on Reta compared to without it (results vary).

Still 24 pounds from my target and it feels within reach.

Appreciate that, interesting seeing how everyone else approaches this. I ramped up on Reta pretty fast myself. Hit 4 total for reta by week two (running 2mg twice that week). Then did 3 and 3 this week. No issues so far. Only real change is the food chatter feels louder overall while I'm just on 7.5 tirz. Still dropping weight at a good clip though and seem to be holding onto muscle, which is really the whole point. Anyway, wishing your friend continued luck with this.

Feels like my own loss has stalled too. Been holding around 87.5 kg for close to three weeks now. Weekly amounts: Week 1: 0.5mg, Week 2: 1mg, Week 3: 1.5mg, Week 4: 2mg, Week 5: 2mg, Week 6: 2.5mg. Shed a big chunk of water weight during week two, about 5kg, then kept dropping roughly half a kilo every couple days before it flatlined. Still feel Reta clearly at 2.5mg. A handful of new side effects lately, nothing serious. Bumping the dose doesn't feel like the right call yet since I'm still under my calorie target and the cravings, hunger, and mental noise around food are all still absent. Staying on top of hydration, electrolytes, protein, and vegetables. Carbs mostly stay reserved for workout or run days. Annoying, but I'll hold steady. Meanwhile got back into the gym, hoping that kicks the fat loss forward.