Reta kicking hypertension's butt!

Just kicked off reta.
Unfortunately even the best outcomes from the study won't move my numbers enough. Given my family history and lifetime LDL exposure, the real target for me should sit under 90, ideally closer to 70.

Currently reading 255 LDL, 23 HDL, elevated inflammation marker, and high ApoB. Honestly had worse cholesterol readings back when I was a fit, active 21-year-old soldier eating clean, so in my case this really comes down to genetics.

Just started a PCSK9 injectable, paying full price out of pocket monthly, alongside a cholesterol absorption medication. Whatever benefit reta adds on top will be genuinely welcome. Every bit helps at this point.

Same here, but my usually-low blood pressure has bottomed out even more lately and honestly it's a real bummer. Thinking I'll pass on the third compound this round and check whether that helps things settle.

Four weeks into Reta at this point, and blood pressure readings that started out pretty alarming, given I'm significantly overweight with a family history of heart trouble, have improved dramatically. Systolic dropped 35 points, diastolic dropped 29. Resting heart rate's fallen a full 15 beats per minute too. Also 15 pounds lighter. Should any of my other labs come back looking rough, these particular gains would still outweigh any bad numbers in my book.

My lipids were always decent apart from high LDL. I did 12 months on tirz and then 4 on reta for the last stretch of weight. More than twelve months passed between checks, and my LDL fell under 100, the first I can remember. HDL is in the 90s now and triglycerides came in at 60 last time. Tirz clearly helped, but I'd credit reta more.

Toni1985 For many years my BP has been handled by a small dose of an ACE inhibitor, effective though. I assumed I could eventually stop it as Reta worked its magic, but it hasn't panned out so far, and maybe never will. I suspect all the years carrying an unhealthy weight, plus bad habits might make it permanent. So it has not made things worse or better. You can't have it all, even on Reta.

Leah B. High BP has followed me for decades, even at a good weight, and three meds still left it a bit high. Right after I began reta my BP sank so low (orthostatic hypotension) that I had to cut doses. These days just one med remains, and I'll likely trim it as well. Trials show BP falling across the board, so I'm probably a textbook case.

Blood pressure is a lovely side benefit of the shot and the weight loss. A modest drop in weight often helps BP dramatically. Seven weeks in for me, and my BP meds are down to a quarter of where they began

It settles down over time. My resting rate was usually 72 BPM, went up to about 82 once i started Reta, and lately its back to 72-73. The good part is that after a while BP drops a lot, possibly from the weight loss.