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the oral delivery development is real and moving faster than most people expected - long-acting formulations that can survive GI degradation and still hit therapeutic blood levels are the technical challenge, and the approaches published so far are genuinely novel. whether injectable forms...

NMNH helping with Tirz fatigue is consistent with what others report - the mitochondrial energy pathway that NAD+ supports can get depleted when you're in a caloric deficit. The cheapest NAD precursor tends to work the same as the expensive versions for most people. Worth trying if the fatigue...

GI at .5mg hits some people harder than expected - tends to settle over the following weeks as the body adjusts.

Stopping in November and keeping the weight off through the holidays is the actual test - the 5 lbs down since shows the habits held.

Burning on Reta injection is usually concentration and pH - acidic solution at higher concentrations hurts more. Warming to room temperature and slowing the plunger both help more than site rotation.

Real talk: track your calories on any app for a few weeks. I stalled for months and had no idea it was the calories. Over a year I lost 100 lbs but portion sizes crept up without me noticing. Once I started logging everything, found out I was way over my target. Dropped calories back down and...

on my 4th shot of grey 60 with the pen. using BD micro-fine 30mm 30g needle. can't get it into skin easy, takes hard pushing and it's slightly painful but no bruising. what am i doing wrong?

what side effects are people dealing with that don't get talked about much? like hairloss, feeling cold, exhaustion... if you dealt with any of those, what helped?

Greek yogurt with protein powder, creatine, chia, raspberries, nuts at 7:45am. Lunch around 1: chicken wrap or beef with sweet potato. Dinner 7ish: steak, salmon, or chicken with sweet potato and veg. These work for my macros on mounjaro. Without it for a bit, I still aim for them but snack like...

Yeah you can totally squeeze the skin on your belly even if you're on the leaner side. I do it all the time. It doesn't have to be a thick pinch either, just grab whatever you can and inject in there. It's subcutaneous so you're only looking at the fat layer right under the skin. And honestly...

I was nervous too but started Saturday and no nausea or GI stuff. Been eating light—protein shakes, bars, sparkling water, topo Chico is amazing. Already down 7 lbs.

Fantasized about losing the weight and living happily ever after off everything — meds, statins, all of it. Then I learned more about my conditions and realized my body still has the same problems underneath. GLP-1s are powerful but I'm not superman. This is a long road.

You might be onto something with the dopamine angle. When I quit drinking, sugar took over. On tirz, my sugar cravings vanished at first. But eventually the dopamine cravings came back for literally anything. Now I get that rush when my next package of compounded stuff shows up. Freezer's almost...

I fully agree with WolfCake that Fiber plus hydration changed everything for me regarding this GLP journey. Zappy Health actually suggested increasing fiber early on and it fixed a lot of stomach stuff.

I dunno, could just be a phone filter or something? Either way, the results are visible!

I take a little bit of magnesium citrate when things get backed up. Not too much, maybe a quarter to a third of the bottle, and lots of water.

the 7.5 jump was brutal for me — three months of bad burps, stomach pain, diarrhea. thought i was done but stuck with it. 10mg was way easier. now on 12.5 with just constipation and rashes at the shot site. if you can hang in there, do it.

I had a similar experience. It started with Ozempic. At the highest dose, I started getting hungry again. Then I switched to Mounjaro. At 2.5mg and 5mg, my progress stalled, but when I went up, my appetite went crazy and I even gained some weight. I stopped completely for a month and then...

Hey BlairPlus -- don't get discouraged about the weight loss being slow. I know someone who dropped nearly 70 pounds on this stuff. It took about a year, but she's super happy and keeps posting bikini pics now, haha. Just keep at it!

Yeah, constipation is a common side effect. I've found that staying hydrated and eating plenty of fiber is crucial. I even use the MeAgain app, and the GLP-1 capybara reminder helps me remember to drink water and eat fiber!