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GHRP-2 requires cycling - pituitary receptors desensitize at continuous use.

The jawline returning at 3 months is the face reflecting what the scale has been reporting - the subQ fat around the jaw and cheeks is one of the first places to show meaningful volume reduction.

Tirz and Reta have partial GLP-1 overlap with complementary GIP and glucagon receptor coverage - the theoretical case for stacking is real, but the combined GI load is the practical ceiling most people find first.

WOW!

Awesome! Which GLP-1 are you using, if you don't mind sharing?

Avery1975, honestly the medication helped me feel full much faster, so I naturally ate less. I focused on protein and vegetables because that's what felt good. Exercise was just walking more at first, nothing crazy!

Thanks everyone for your kind words! Scale-Fit, it took me from September 2024 to February 2026, so about a year and a half 😊

Thanks! It's been a journey that's for sure. I see a big smile on your face too!

I'm 33, 5'5", started at 265 lbs around September '24 and now I'm down to 130 lbs as of February '26! That puts my BMI at 21.8. I'm currently using 10 mg, but I am figuring out how to slowly reduce my dose. Mounjaro has been a game changer, it's helped both my body and my mental game so much...

Yeah, it's a moderate interaction. Keep an eye on your glucose levels to see if you need to adjust your hydrochlorothiazide dose. https://www.drugs.com/drug-interactions/hydrochlorothiazide-with-rybelsus-1276-3617.html

A 100 lb loss looks amazing!

Way to go, girl! Congrats! We started around the same weight, and I just accomplished my 100-pound milestone too! We got this!

That's awesome progress in just three weeks! Keep it up! What dose are you on?

Huge congrats on your progress! I just started on a similar journey. Took my first 0.25 dose a few days ago and I've already seen a little movement on the scale. I wanted to try a different med, but insurance wanted me to start with this one first. Anyone else experiencing frequent urination...