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  1. PipNotes

    Down 40lbs! Feeling amazing!

    That color looks fantastic on you! Keep up the awesome work!
  2. PipNotes

    Reta + Survo + Cagri... Overkill?

    I agree with Maxie81, approach with caution! I've had great results, but I've stuck with known quantities and adjusted slowly. Mixing things could easily backfire.
  3. PipNotes

    Reta + Survo + Cagri... Overkill?

    Hey everyone, Just wanted to share my GLP-1 journey. Started in early 2024 with one, then moved to another, settling on 7.5mg weekly, which worked well. Then I tried Reta and it was pretty effective. I initially weighed around 290lbs, aiming for 220lbs, but I actually got down to about 205...
  4. PipNotes

    This actually works?!

    Oh my gosh, isn't it unbelievable?! I've lost 40 pounds in 3.5 months. It's like magic!
  5. PipNotes

    Same pants, 9 months later!

    Impressive results!
  6. PipNotes

    Same pants, 9 months later!

    What was your starting weight, if you don't mind me asking?
  7. PipNotes

    Down another size! Whoop!

    Amazing !!! I went from an 18/20 (sometimes even a 22 depending on the brand) down to a size 14. I actually cried in the dressing room when I tried them on because I couldn’t believe it.
  8. PipNotes

    Down another size! Whoop!

    Congratulations 👏🏼 👏🏼 👏🏼 👏🏼
  9. PipNotes

    Amycretin - the next big thing?

    Good thoughts I am wondering if there is a synergistic effect beyond what one might expect from just stacking a GLP-1 with an amylin analogue. We will have to wait and see.
  10. PipNotes

    Amycretin - the next big thing?

    Exactly my thoughts. It's time for someone to get to work on amycretin, or MariTide, or whatever other peptides are coming down the line. There's definitely a market for it.
  11. PipNotes

    Amycretin - the next big thing?

    Novo is working on a successor to cagrisema called amycretin, which targets both GLP-1 and amylin receptors. Phase 1b/2a trial showed some encouraging results, upwards of 20% weight reduction. Stock prices jumped about 8%. www.novonordisk.com
  12. PipNotes

    This med is making me a new person!

    Congrats!!
  13. PipNotes

    This med is making me a new person!

    Pics don't show it? Girl, you're hot stuff now (kidding, kidding). You look amazing, and I'm happy for you. You're healthier, and you've set yourself up for a great life. Congrats, and you'll hit your goal weight in no time. You're smashing it!
  14. PipNotes

    Nausea on GLP-1s: what helps

    Great thread. I will add one small thing: injection site rotation did change side effect intensity for me. Abdomen was harsher, thigh was milder. Totally anecdotal but worth experimenting if someone is miserable. And to Bee_Loss, early weeks can be rough. If you are bedridden or cannot...
  15. PipNotes

    Down 100 lbs! Pics!

    Fingers crossed I get similar results. You look amazing!
  16. PipNotes

    Down 100 lbs! Pics!

    You look like a new person, congrats! You must be feeling great.
  17. PipNotes

    GLP-1 Titration: How often y'all upping?

    Based on trials and research, many dosing protocols prioritize medication adherence. For example, while daily tirzepatide administration might be optimal based on the half-life, pharma dosing is weekly because this has the highest adherence rate. The higher dropout rate in trials may be due to...
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