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I’ve used wegovy for about 2 months and am down almost 22 lbs. I experienced nausea and struggled to eat the first 6 weeks. Things have improved the last couple of weeks. I've been on the starting dose the whole time.

Honestly, nothing much happened when I stopped in August of last year. I haven't put on any weight. I check my weight every few days and am careful about what I eat. I lost around 30 pounds and was only on a .75 dose. It does make me a bit anxious, though.

I did lose some pounds immediately on .25, BUT only because I was carefully tracking my caloric intake and maintaining a deficit. If I hadn't been so diligent with calorie counting, I doubt I would have seen rapid weight loss. Your initial weight and efforts to reduce calories impact how...

BP normalization, snoring gone, and pulse that low is the full cardiovascular signal - that's the trial data showing up in lived experience. Most people on Tirz report the side effect profile smooths out by the third or fourth dose step.

week 2 nausea was brutal for me, basically lived on crackers and ginger ale for 4 days. try super small portions, even just a few bites at a time. breakfast sandwich was probably too heavy when your stomach's already upset. stick to bland stuff and eat slow. the food noise thing is wild...

This is so true. The mental shift alone is huge. Instead of thinking about food all day, thinking about workouts, meal planning, clothes that fit—I can just live. Still stuff to work on, but now I have actual space in my brain for other things.

doesn't really matter. once it hits living tissue it takes on the body's pH super fast. we've got natural buffers keeping pH tight, so even if it goes in at one extreme it'll equilibrate quick. not saying inject something crazy painful, just saying temperature comparison—goes in hot, arrives at...

Interesting. I have heard that some studies have been done on nasal sprays, but not tablets. I miss reliable ghrp6!

Where are you finding lido with epi? Lidocaine is easy to get, but with epinephrine? Don't you need a script for that?

That's a good question Bear_Fam. It seems like people have different experiences when trying to maintain. I've seen some people say they have to keep increasing the dose to get the same effect, while others do well on a very low dose.

From a research view, I get the placebo arms. But, to me, that's for those getting the placebo from the start. Not putting people on a life-changing drug and then taking it away. But, everyone eventually gets taken off the meds. No free ride forever. Is it better to have loved and lost than...

Yeah, it feels wrong to take people off meds, especially later in trials when we know the meds are safe and work. But we learn a lot from these trials, and people know about the placebo groups before joining. Still gotta suck. Imagine being on trizepatide for 9 months and then being taken off...

Thanks for sharing! Just to clarify, this article isn't about the actual SURMONT-4 trial, which was out last year. This is a new look at the Surmont-4 data, analyzing how heart health changed based on weight regain after stopping tirzepatide. To me, this chart from Surmont-4 always pointed to...

Has anyone seen this SURMOUNT-4 study? Basically, folks who were obese used tirzepatide and changed their lifestyles (cut 500 calories daily and exercised 150+ minutes weekly) for 36 weeks. Then, researchers divided them into two groups: one kept taking tirzepatide, the other got a placebo...

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For those of you just starting out, I've found that injecting on Thursday mornings helps cut those weekend cravings!

I combine sema and tirz myself. I inject them both on the same day. My hunger comes back around day 6 on sema, so splitting that dose also makes sense. I'm not too strict about the exact schedule. As long as it's consistent each week, it should be fine. Sometimes I'll add a little extra sema...

That's so true! I've been lifting heavier and seeing a difference in toning. You don't bulk up easily. It takes work!

I take a liquid collagen shot post-workout. 25 grams of collagen peptides per serving. That’s a lot for the price. Studies show that around 15g daily improved joint conditions in older adults. https://www.amazon.com/dp/B0734RHXS3

I'm so glad to hear about your success, FiberLean! I've been on a similar journey myself. Started around 410 lbs back in February, and I'm down to about 340 now. Still have a ways to go, but for the first time in a long time, I actually feel good about how I look. It's a game changer!