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What about NAD+? Sorry, I'm pretty new to this. MotsC gets named all over the place, but NAD gets plenty of posts as well. Where does it fit in here, and how frequently do you take it?

Count me in this club too, though mine followed fast weight loss before any GLP-1, with tons of fasting. Gallbladder attacks hit me repeatedly before the last one, one during a cruise (months of restrictive dieting plus a week of gluttony, no shock). What finally sent me to the hospital was just...

I was on 1mg, then back on 1mg again, a trip that took April to August. I wonder about pushing to 1.25mg. My intake is lower than before and I stay about as active.

My guess is a fair number of us are walking around with insulin resistance that's never been diagnosed, so wanting less coffee might just come down to this medication finally letting your body pull the energy it needs from whatever you're already eating.

I think you're onto something with that reward-chemistry angle. The mind finds its outlet no matter what. When I gave up drinking, sugar stepped in as the substitute. Once I started the third compound, my sugar cravings got wiped out almost immediately at first. But eventually that same...

Most people say Tirz wins on appetite suppression, at least early on. Real noticeable suppression tends to show up within a day of that first shot. From what I've read, Reta's suppression doesn't kick in until you're up around 4mg weekly. That wait can be brutal if you're impatient like me and...

I've got Type 2 diabetes as well. My A1C went from around 9.1 last October down to 5.6. Next round of bloodwork happens in July, curious to see how it looks by then. Wish this medication had existed two or three decades ago, though I'll happily take late over nothing!

Hit goal weight, currently holding maintenance at 1mg every 5 days (topped out at 2mg every 3 days at peak). Weight's stayed steady the past three months.

My guess is a lot of people just can't tolerate the bigger doses. For me, blood sugar's stabilized, blood pressure meds got cut back, and I'm down 60 pounds. Sitting at 4.5 now after a really slow climb over seven months.

It's really just a mental lag from the weight dropping so quickly. Doesn't happen for everyone, but it's mostly just a matter of your brain catching up eventually.

Oh, I use a similar progress-tracking app too! Genuinely useful since I'm terrible at remembering to snap photos of myself throughout this whole journey. Love it!

Congratulations!! That's absolutely wonderful. You must be feeling incredible. So genuinely happy for you.

Lost all interest in potato chips since starting this. Used to go through bags of them like nothing. Thankfully my taste for a drink is still fully intact.

Congrats! How's maintaining it treated you so far, made any major changes to your routine or just sticking with the same approach?

Wait, so you're saying skip eating entirely? Usually the gut trouble from these meds traces back to greasy or spicy foods specifically, not a total inability to digest anything.

30 down with no one saying anything is such a frustrating but common experience. The person who sees you every day doesn't clock incremental change - it takes stepping back from someone who hasn't seen you in months. The mirror and how clothes fit is the better signal anyway. You know what's...

It's purely the weight coming off, losing facial fat is what creates that younger appearance, happens with any significant weight loss regardless of method.

Thigh is the most reliable spot for consistent depth and absorption. Some people find rotating between multiple thigh sites vs the same spot reduces the soreness that builds up over time. Worth trying the other thigh if you have been using the same one consistently.

6 from onederland myself, so reading this thread hits different. Congrats on breaking 100 - that's a number that takes a while to really land.

The Cagri and Tirz combo hitting hard in the first few days is consistent with what a lot of people report. Taking a break within the run is a good way to manage it when the sides get too much. How many calories are you managing to hit on the worst days?