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The Alzheimer's trial results were mixed - the endpoints weren't met the way Novo hoped, but the interest in GLP-1 effects on neuroinflammation and cognitive function hasn't gone away. There's enough signal in the broader research that the space isn't closed, just not confirmed yet.

At 4mg the effect tends to accumulate over the first two to three weeks rather than landing as a single moment - the 'always feeling it even before the next dose' is the signal that it's built to a steady state, which usually takes a full month at any given dose.

Setmelanotide is a melanocortin receptor agonist - different pathway from GLP-1 entirely.

That's a great idea! I will definitely ask about splitting doses. Thanks!

Thanks, everyone! I feel better knowing it's probably just body recomposition and not the medication stopping working. I'll start measuring myself regularly.

I began with .25mg in January, and my doctor suggested increasing the dose each month until March. I moved to .5mg in Feb and am now at 1mg for March, with another appt coming up. I started at 205lbs. By February, I was around 195lbs. Now, my weight is still 195lbs. I almost don't believe the...

I do weekly weigh-ins too! Daily can drive you nuts. Your weight goes up and down based on a million things. Weekly gives you a better overall picture.

Good! Advocate for yourself!! There's usually something to tweak or try.

Sorry to hear that, Sam_93. Did you talk to your doctor? Maybe something medical is preventing it from working? Also, hard truth time: even WITHOUT GLP-1s, if you're eating less calories than you burn and you don't have medical issues, you should be losing weight. GLP's are great, but you still...

That's an awesome point, LeanStrong. The reduced pressure on my joints has been a game-changer. I feel like I can actually enjoy moving again!

Don't get discouraged! It's a marathon, not a sprint. Are you tracking calories and macros?

Thanks everyone!!

That's awesome! Those non-scale victories (NSV) are sometimes even better than seeing the number on the scale drop.

Just hitting my 8th week now, and I've dropped about 28 pounds. It's wild how much better you feel when you're eating right and getting exercise. My joints feel so much better, and my mood is way up. Can't wait to hit my goal of 250!

Totally! My little belly above my hips has shrunk, and I look more toned even if I haven't lost loads of weight yet.

Super curious, please update with any news. I've experienced some hair loss lately too

Great work

Amazing. Nicely done!

Seriously, with all due respect, it's like looking at twins!

You're glowing, you're your authentic self! Congrats on your achievements! 🥰🙏🙏💜