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The psoriatic arthritis connection is worth considering - GLP-1 has direct anti-inflammatory effects independent of weight. Autoimmune conditions often respond.

The menopause weight gain hitting hard while also having a history with disordered eating creates a particularly difficult relationship with the scale - the medication helping break the cycle is more meaningful than just the number dropping.

Day one appetite response is more common on tirz than sema - the dual mechanism hits faster for a lot of people. Half a kilo weekly is a reliable pace that holds better than faster starts because the metabolic baseline stays stable underneath it.

I find I'm just eating less, and I'm full pretty quickly. Also, I'm not interested in snacking much anymore. I'm not weighing my food or anything. I'm hoping the weight will come off.

I started 2 days ago along with metformin. I did research on my own first. Please do your own research as well. This is just my experience and how I understand the benefits. Talk to your doctor. Day 1 was fine, day 2 my appetite was the same, but I could only eat half a bag of salad for...

I saw on Reddit someone saying they keep old clothes to try on. They said it helps them see the difference. Might be worth trying?

I heard Skims are good. Some other brands to consider (do your research!): * Knix * Spanx * Shapellx * Shapermint * Oqq * Feelingirl on Amazon * Honeylove

Thanks for all the advice everyone! I'm going to pin this afternoon.

Still haven't started my Tirz. Woke up with norovirus the day I was supposed to pin! So, starting next weekend with a -10lb head start!

That's amazing A1C_Warrior! Congrats! I hope I can be half as successful. The hardest part for me is finding the energy to work out. I know I just need to make myself do it. I'll start this weekend.

Wow, congrats on the weight loss PulseBTW445! Thanks for the advice. I think I will start tomorrow. Avoiding holiday weight gain sounds great. Constipation worries me though. What helped you manage it?

Got my initial tirz order. Paid a premium to get it fast from a domestic source for a trial run. Two questions for the experienced folks: Did you stick to the standard titration or hold dosages until they stopped working? I'm thinking 2.5mg to start, holding until it loses effectiveness before...

Nice progress, MoodyPath646! I started Reta about a month ago, at 0.5mg, and just bumped up to 1.0mg. Haven't seen much weight loss yet, but it's been the holidays, so my diet hasn't been the best all the time. I had some mild nausea the first few days, nothing major.

Dude, same! People think I'm starving myself, but I just wrapped up 8 weeks on Reta and some growth hormone, and I'm down almost 40 while actually gaining muscle.

Hey guys, I'm new to this. Is there like, a standard amount of bac water to add to a vial? Like, if I get a 5mg vial from a research site, how do I know how much water to add?

There's no such thing as a dumb question. Leave the thread up.

That's awesome!

I don't have a gallbladder anymore and I've injected all over, including my stomach.

I lost some hair, had short-term stomach problems, then my gallbladder had to be removed during the whole time I was on the drug 😍 and I regained all the weight after the surgery because my body couldn't process foods correctly anymore.

Not DKA, not paralysis, not eyesight issues... I put a new needle on my injector pen last night, then dropped it. It made a long scratch on my leg (where I jab). It bled a ton! At least I haven't had diarrhea in public, so that's good.