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40 lbs and both the physical and mental shift - the medication-as-tool argument ends when the food noise actually stops for someone.

CRP and IL-6 are the measurable markers for systemic inflammation - a basic panel before starting and again at 3 months gives you objective data beyond the feel.

99 down and still moving is the combination that actually sticks.

I stack mag glycinate and melatonin at night. Glycine same time if I add it. Then a handful of vitamins after my first meal. Creatine I try to time before the gym.

Finally under 100kg feels real. Gained a lot in 2024, noticed health impacts in 2025. Doctors, blood tests, ultrasound — fatty liver. Started trying in July, changed my diet but stuck around 100kg. Over 4 weeks on this med now, 5 shots at 2.5mg, and I've hit double digits. Much easier than before.

i make fancy drinks every morning—ice, lemon/lime, electrolytes in mason jars with straws. people ask what i'm drinking cause it looks so good. keeps me drinking way more water & stops the constipation issue.

Not saying others should do this but I'm stacking sema with a little of the other one for inflammation and appetite control. Sema's cheap so I'll keep it until it stops working. I'm at 1mg sema plus 1mg of the other weekly, sometimes an extra 0.5 of the second one if I'm hungry. Moving up slow...

These meds are basically a miracle. I use ivim health and it's been huge.

yeah, the shipping on the first order costs something but it's still way less than you'd pay retail or compounded. keep in mind though—some people can't handle these meds at all or need to titrate faster than planned to see benefits. lots of unknowns.

Anything more than a single drink and I'm awake all night feeling like I'm gonna hurl. It's awful.

You went from 15mg of Tirz to ~2mg of Reta, RXPete? Why not up your Reta dose? It doesn't make sense to go from a 'max' dose to less than a 'starting' dose and expect anything to happen.

I take 5mg of Reta on Mondays and 8mg of Tirz on Thursdays. I might adjust that again at the end of the month.

I'm starting to wonder if the GHRP peptides are interfering with the Tirz effectiveness. It could explain why I'm not feeling the appetite suppression as strongly as some others do. Maybe I should experiment by stopping them for a short time and see what happens?

I saw someone else post about finding their dream wedding dress after losing a bunch of weight on MJ. These meds are life-changing!

Thanks for the warning about tesa. I was thinking about adding it as I get closer to my goal, but if it messes with my appetite, I'm definitely waiting until I'm at my ideal weight.

Congrats!!!

It sounds like everyone's experience starting tirzepatide is different. Some people feel the effects right away, while others need higher doses or more time. And side effects seem to vary a lot too. I felt the effects within about 3 hours of my first injection and haven't had many side effects...

Hey everyone. I began taking Tirz two weeks ago, at a dose of 2.5 mg each week. So far, two injections, and I haven't noticed any reduction in hunger or those constant food thoughts. I did have some mild stomach upset and diarrhea, which I know are common. I'm also taking a few other peptides...

Congratulations 🎊 🎉 🎊 🎉

Amazing!!!! How tall are you? This is truly inspiring.