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I wouldn't lower the dose yet. Mounjaro has a 5 day half life, so hunger might come back over the next two days. Week 1 tends to hit hardest since you go from nothing to drug in your body, and week 2 and after at 2.5mg feel weaker. If you're still struggling after 4 weeks, then think about...

Anxiety got worse for me after the jump to 5mg. Now at goal, I'm back on 2.5 and the anxiety is a thousand times better. I feel way better there. Just hoping 2.5 is enough for holding my loss.

Two years on mounjaro now. Went through stretches of both diarrhea and constipation early on. Barely notice side effects these days. Rough at the start, but pushing through was worth it completely. Every health marker's improved. Off blood pressure medication entirely, 50 lbs lighter (began at...

Loyal user of the dual-action medication here, and honestly reading through what you need, that one sounds like the clear fit. The single-pathway option tends to hit people with rougher side effects.

Personally preferred this alternative growth-hormone releasing peptide over the usual one while running the third compound alongside CJC. Bumped my IGF-1 numbers up noticeably more, somewhere around a third higher if my bloodwork memory serves, and the extra hunger actually worked in my favor...

Same boat entirely. Reta genuinely amplified my trouble getting started on things, enough that roughly half my scheduled training sessions got skipped. Fair to say focusing at my office job already gave me trouble before any of this, but I basically never bailed on an early workout, mostly...

Yeah, people have shared their results here, myself included, but most of us are stacking with tirzepatide while the original question was specifically about retatrutide. That said, I'd guess the effects run pretty similar between the two. The two accounts that come up most often are from a...

Nice to know those eggy-tasting burps without eating eggs aren't just in my head! Only started last week, two doses so far, a week apart, at a small starting amount. Stomach's a bit unsettled most of the day, and honestly nothing sounds appetizing right now. Those sulfur burps genuinely caught...

Stack both here too, though I hit the tirz ceiling before ever touching reta. Ran 15mg tirz until it flattened out completely. That's when reta got added. Currently doing 5mg reta alongside the 15mg tirz. Broke through the stall and I'm sitting around 30% of my starting weight gone.

Congrats on getting to where you are! Skin might just need a little extra time catching up to the rest of you. Stay on top of your water intake. Wishing you the best!

Was in a nearly identical spot myself, and six months later I'm 16 kilos down and sitting right at my target. I'm on the older side at 61 and had spent a full decade failing to shed this weight before. Barely dealt with any side effects, just make sure to drink plenty of water once you cut back...

Makes me question whether that's actually reta at all. Sounds more like edema, which usually comes from GH secretagogues instead. Only recently started seeing vials come back mislabeled during testing too.

Order whatever looks appealing, eat until satisfied, then stop there. Never feel obligated to finish everything on the plate. Tend to look for smaller portion options anyway, knowing the full dish won't get finished regardless.

The reset question comes up constantly and the data does support staying on rather than stopping and restarting. 4mg with room to go and still seeing results is the position you want to be in at this stage. Pre-diabetic to not is genuinely life-changing at the metabolic level - how long did it...

250 to 183 at 0.50 and still losing is the case for not changing what's working. The OP at 460 to 268 is a different starting weight and the mechanisms scale - but the principle of staying at the lowest effective dose is the same. If the loss is still happening at 0.50, there's no reason to move...

The Scientific American episode is a good accessible overview for people who want the research narrative without going into clinical papers - the history of how GLP-1 was discovered from Gila monster venom through to current medications is one of the better science origin stories.

Perimenopause plus GLP-1 where the mechanism is suppressing appetite enough to keep the deficit real even on very low intake is a specific combination. Fighting for every pound at sub-1000 calories is where the medication doing the appetite work matters most - the alternative is a deficit too...

The self-esteem framing is the piece that maps most directly onto the relationship patterns people describe - when the baseline sense of what you deserve or what's realistic is calibrated down by years of how you've been treated, the partner choices that followed that calibration don't always...

The insulin parallel is the most useful frame for traveling with injectables - insulin users carry temperature-controlled supplies through airports and hotels without disclosure or explanation, and the same expectation of medical privacy applies. A diabetic supply travel case does everything a...

Three years with alcohol nearly out of the picture is the long-duration data point on the reward circuit change - it's not just novelty or a temporary suppression, the mechanism is holding. The one-and-done capacity is exactly what most people describe as the most notable change: not the absence...