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Congrats! I just started MJ, with a similar starting weight. I'm in week 6 and just moved up to 5mg. Did you follow any exercise or eating plan early on? I could use some motivation.

My current target lands right below the 25 mark on the BMI scale. Weighing whether to set the real number a touch lower still, giving myself some cushion to stay comfortably in the healthy range while working out the right maintenance approach.

Starting weight 260, currently 172, from July of last year through today. Ran one month on a compounded amount around two milligrams, then moved to an unregulated version for a month each stepping up through the mid-single-digit range, and I've held at a solid dose since November. Eventual...

Agreed, stick with 2.5 if the weight's still coming off. My insurance though would only cover a 30-day supply at that amount, so bumping up became the only real option available. Turned out to be a good change for me, definitely felt the extra kick, makes sense since it's basically double the...

0.5mg is the right cautious start and not expecting wild appetite suppression at that level is accurate. 3 lbs in the first week on 2mg is a strong early result - that kind of response at a higher starting dose is what makes people stick with it. Control over dosing is one of the real advantages...

the ASA guidance update is meaningful for people planning surgical procedures - the newer protocols are less restrictive about GLP-1 continuation before elective surgery than the older guidance, but implementation is uneven across institutions. if your surgical team is using the more...

six months in with that kind of result is genuinely motivating to read. the slow walk and garden routine is exactly the kind of sustainable activity that compounds over a long protocol. good work

Making a travel vial from the main supply so the original isn't temperature-cycled is exactly the right call. Keeping it room temp for the short vial life rather than worrying about fridge access on the trip removes a logistics headache. TSA usually doesn't flag small vials when they're clearly...

Eyesight getting worse since starting GLP-1s is its own interesting side report that keeps coming up. The OP's friend testing the substance and getting a result back is more useful information than most people have going in. The article context would help a lot with interpreting what 'some...

The hyperfixation on GLP-1 as the single mechanism is a good point. The commercial response trying to replicate the effect through supplements or natural approaches is chasing the outcome without understanding the receptor pathway. WW's challenge is that their model assumed the behavioral...

28 down and 18 down at 6 weeks is a solid early result for both. Regretting not starting lower is the most common thing people say after jumping in. Have you noticed any difference in how the two medications feel day to day beyond the weight numbers?

the site-dependent absorption difference is one of those individual variables that doesn't show up clearly in trial data but has consistent community reporting behind it. abdomen versus thigh for most people produces a different onset feel and for some a different side effect profile. rotating...

3 months of feeling like crap on Sema and then switching to Tirz and feeling much better is the reverse of what the OP is dealing with. The individual variation in which direction causes more GI issues is genuinely unpredictable. Starting low and slow is the right advice regardless - 5mg on the...

The protein craze framing as aging and muscle loss concern is fair but the mechanism is more specific when GLP-1s are in the picture - the rate of intake reduction these medications drive can be faster than what resistance training alone offsets. The OP's struggle with meat and beef for...

Fatigue and anhedonia on the active loss doses and then dramatically better at 1mg/week maintenance is useful context for the OP who's 22 lbs in at 1mg and already feeling the flatness. The question is whether the numbing is dose-dependent - if the therapeutic dose is producing the feeling, a...

Compounded tirz pricing varies by provider - the $160 range is realistic but cost per week depends on concentration and dose. Pharmacy route is pricier but has quality verification.

Oral sema has almost no bioavailability - most never makes it into circulation. Injected is entirely different.

Progressive resistance training added early makes a real difference - the muscle growth underneath tightens the surface more than time alone.

Your a1c jump (7.8 to 5.1 in 5 months) is really solid, plus 19lbs is solid progress. What you're describing at 10mg is common—appetite suppression gets so strong eating feels like nothing. You shouldn't dread meals. Talk to your doctor about dropping back to 7.5mg.

800 calories is way too low and risky. be careful your body doesn't shut down on you. jumped straight to some peptides without building up first and it was rough.