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Splitting R140 into vials on reconstitution is the right approach for dosing flexibility - figuring out the amount before committing is worth the extra step, especially on a compound with a narrower margin than standard GLP-1s.

Cholecystectomy history from obesity-related gallbladder failure is the common pattern - that's a different risk profile than idiopathic pancreatitis, which is the relevant GLP-1 contraindication. The distinction matters for whether the prior history actually changes the prescribing risk assessment.

What do you folks do when a craving just wont quit? I usually eat some carbs like bread if it gets really bad, and that seems to do the trick.

2mg to 3mg with 16% over 3 months is a strong early curve - the plateau at maintenance dose is expected and usually temporary. Most people find the loss resumes after the body recalibrates at the new dose level, typically 3-6 weeks in.

That is so true! These meds can really curb your appetite, and it's easy to undereat. It's so important to be mindful of getting enough protein, vitamins, and staying hydrated. Maybe talk to a registered dietician for a few sessions.

I get them pretty much every time, and I'm on 10mg. I get a big welt at the injection site that itches all week. I try to dab the area after injecting to soak up any leakage, and that sometimes helps a little. But the best way I've found to ease the itching is to use cortisone cream several...

Definitely stop the injections and finish the steroid treatment. Take antihistamines as prescribed. I wouldn't try anything in the tirzepatide class again if I were you, as a reaction like that could be deadly. Maybe after a few months, try a different medication like Ozempic or Wegovy at the...

I understand the struggle. Another thing to consider is the potential impact of antacids. I've seen cases where long-term antacid use actually worsened reflux symptoms. Everyone's different, of course, but it's worth exploring all possibilities with your doctor.

One donut would've done it. Reading this gives me burps. Did something similar after 3+ years on the med at work—at least it was over quick when I puked. Sticking to the boring bland diet now between doses. Lesson learned!

Thanks for the responses, everyone! It's helpful to hear different experiences. I'll try to be patient!

I recommend daily fiber gummies and, of course, plenty of water.

I've heard that. Have you looked into "mechanical eating"? Setting alarms and eating small amounts at set times to make sure you get enough calories and protein?

If all else fails, Milk of Magnesia can provide relief. But use sparingly.

I also noticed Costco usually has fiber supplements for a better price.

I'm on week 2 of a 4mg dose. I'm noticing my hunger has decreased during the day--just eating lunch and dinner, and not huge portions. But I'm still feeling hunger. How long did it take for the medication to really kick in for you? And did you stop feeling hungry, or is there still some hunger?

I hit a year without cigarettes today. Mounjaro had a big part in that.

Anyone else dealing with slowed digestion since starting semaglutide? I'm about two months in, and things just weren't moving as smoothly. I started adding a fiber supplement to my morning routine with my meds, and it's been a total game changer. Everything's back on track, and I actually feel...

Awesome progress!

So happy for you, you're doing amazingly!!! Isn't it life changing!

I understand... everyone's situation is different. But, you don't sound that overweight to me. 5'11" and 227 isn't terrible, especially if you're muscular. Sure, losing 15-20 pounds would help (true for most people?), but you could do that over a year with small changes. From what I saw with...