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The sweet spot between 0.25mg and 0.5mg for sema exists but isn't available as a standard pen dose - some titrate by splitting doses differently or timing them mid-week. If 0.5mg side effects are mostly front-loaded, tolerance usually builds within 4-6 weeks at that dose.

The scale stall is often the body recalibrating after a fast early phase - measurements, how clothes fit, energy levels, and sleep quality are all tracking changes the scale doesn't capture. Progress markers other than weight tend to show more consistent movement during a stall.

Skipping a week and resuming at the same dose is the standard approach - no need to step back unless the gap stretches further. Half-life gives more flexibility than the weekly schedule suggests.

To Mike_1977, some patients do experience mood changes on these meds. Since you were already being treated for depression and anxiety, it's really important that you discuss this with your doctor ASAP. They might need to adjust your antidepressant or evaluate if the medication is the right...

That's fantastic! To HeartSquad, it's important to discuss your lack of progress with your prescribing physician. Dosage adjustments are usually based on individual response and tolerance. It's not uncommon for progress to be slow initially, but your doctor can assess if the current dosage is...

NSV's (non-scale victories) are a big motivator! I went from an XXL to an XL. Huge!

100 lbs is huge! I'm at 90, and I don't see it either. I think it's psychological. I'm coming up on a year in April. I hope I'm at 100 by then. I feel great, but my brain hasn't caught up.

Yes! You look fantastic! 100 pounds is a huge difference! You look great! Congrats!

I do the shot every 10 days and have gone from 1mg to .75. I'd still like to lose another 5-6lbs, but that'll mean tracking my macros, so I need to get into that mindset.

If you're not seeing it yourself, remember the 'paper towel effect.' The more you lose, the harder it is to notice the difference.

I've been in maintenance mode for about 2 months now. Still injecting once a week, but I've lowered the dose a bit and I add more calories on the weekends. I got into a routine of eggs for breakfast, crackers/cheese for lunch, and a salad with chicken/shrimp for dinner. Balance is important, and...

I saw someone mention that they are doing this for their kids. I think that's wonderful, and relatable! I know someone who was diagnosed with T2D, despite having already lost 100 pounds through diet and exercise! GLP-1s can be great for controlling diabetes and just feeling better and being more...

That's why they say to combine GLP-1s with therapy, but usually people dont do it until something goes wrong. Obesity is an illness, point blank! We eat for emotional reasons. We try WW, diets, Keto, fasting, even surgeries. And its in the brain, its addiction: so we bandage the wound, but dont...

Congrats on the weight loss, A1C-Slayer! It's great you're thinking about maintenance already. One thing to consider is that GLP-1s can have benefits beyond weight loss, such as improved blood sugar control and potential cardiovascular benefits. Even if you reach your weight goal, a lower...

That hunger coming back after a year sounds alarming, T2D_Survivor_Mark. It's understandable you're feeling uneasy. But the silver lining is your body gave you quick feedback, and your doctor reacted fast. Here's what may help: 1. Track more than just weight: appetite, energy, sleep. These can...

I completely agree with It's wild how much your life improves when you regain mobility and reduce your reliance on meds. Keep crushing it! Just be sure to listen to your body and make sure you're getting enough nutrients.

Losing a great deal of weight is WONDERFUL!!! Pay no mind to the foot comments. Once I went below 300 taking care of my feet was hard! I'm now at 190 and they are much easier to reach!

I tried explaining my money-saving plan to my doctor, but either they were not understanding, or there's some unknown reason they couldn't prescribe a larger dose.

My spouse became pregnant and stopped using a pen that had 3 doses left. It was in the refrigerator for 3 months before I tossed it. Before I threw it away, I tried to empty it by putting a needle on it and counting out a dose, but the button wouldn't work, and the dial wouldn't turn on.

Great job!! Keep it up!