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Cravings on the second injection track with hormone cycle interaction - the GLP-1 effect on ghrelin gets disrupted mid-cycle.

The loopy or slightly off feeling in the first few hours is the GLP-1 receptor activation hitting the brain - it comes before the appetite changes and normalizes after the first 2-3 doses for most people.

204 to 123 in a year changes what the next decade looks like. The forum being part of that is real.

Okay, okay, I'll spill! SW was around 360, current weight is about 230, goal is another 30-40lbs. I try to walk most days, nothing crazy. Diet is mostly just smaller portions and more protein. Some nausea at first, but it's mostly gone now.

Wow, thanks everyone! You're all so supportive!

I'm pretty new around here but I'm already so impressed with the support I see! I'm feeling really good about my progress so far but still have a ways to go!

Wow, reading all this is both encouraging and a little scary! I'm down about 30 lbs, and my A1C is so much better. Maybe losing the butt is worth it?

Not my butt, but my boobs have definitely shrunk!

Hey everyone, has anyone else noticed their butt shrinking? I've been on this for about 12 weeks, and my rear end is getting flatter by the day. My weight loss is pretty gradual, but still... any advice from those who are further along? Will more glute exercises help bring it back, even a...

So amazing, honestly the best feeling ever!

Thanks for posting! Just a reminder about the rules...

I eat a pear every day.

I use stool softeners too

Smile! Seriously! When you feel like you're going to be sick, smile as big as you can. A nurse taught me that when I had my baby. Worth a try!

If I have a light meal the day of and after my shot, that helps. I also avoid alcohol at all costs on those days. I drink a ton of sugar free ginger ale.

There's no real need to dose more than once a week if you can handle the side effects. The drug was designed for weekly dosing; it's more effective that way. Stick to the same dose for at least 4 weeks to reach a stable level in your system.

What a truly beautiful feeling

That's my starting weight and my goal weight, too! After dropping the first 20-ish pounds, walking and stairs got SO much easier. How long did the whole process take?

I inject daily, and I'm not sure how a doctor would monitor more frequent dosing. If you use the brand name pens, splitting is physically difficult (I've done it with Zepbound, but it's not easy). Even though I inject daily, one argument against more frequent injections is that Tirz was tested...

I was taking 5mg weekly, but had really awful diarrhea for a couple of days, with a day to recover. So, I've decided to lower my total weekly dose and split it into 1.5mg twice a week, gradually increasing it. I saw something online saying this might help with side effects if monitored by a doc...