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Insurance prior auth criteria for these medications almost always focuses on BMI and weight loss percentage rather than metabolic markers, which is a disconnect from the clinical evidence. The blood sugar improvement alone is a valid medical argument - the prescriber pushing back with A1c and...

The alcohol shift is one of the more consistent surprises - the cross-reward suppression GLP-1s cause hits the wanting response across the board, not just food. Cured meats and rich cheeses tend to follow once satiation kicks in earlier than expected. The flavor appeal stays but the volume...

38 lbs in 6 months at a stable dose is a solid trajectory. Forced titration schedules don't always serve people who are seeing consistent results - if 2mg is still working, staying there is a legitimate position.

I'm going up a dose myself. So excited! But also a little nervous.

Third dose Thursday and today I feel hungover without the booze—dry mouth, constant thirst, fatigue, brain fog, that shaky feeling. Had a small piece of carrot cake and wondering if the carbs spiked my blood sugar because this is exactly how that feels.

The studies showed more weight loss with higher doses, so I'd guess increasing it would help. Instead of switching completely to Reta, maybe add a little to your current Tira. Like, keep the 7.5mg Tira and add 2mg Reta. Might give you a boost.

Yeah metabolic adaptation slows progress but can't actually stop weight loss if you're in a deficit. What's more real is as you lose weight your calorie burn drops. Heavier people burn way more just existing. You might be eating the same but now it's at or above your expenditure.

It really is a game-changer, not just for weight but for a bunch of other stuff too. But yeah, if that study's what I think it is, those numbers are from guys with diabetes, not just regular guys. Would love to read the full article but can't get it from work.

anyone mixing two peptides in one vial? i do 150mcg IPA and CJC each morning and night—syringe juggling is annoying. thinking: reconstitute one vial with bac water, draw that into a syringe, use it to reconstitute the other, add more bac, end up with one blended vial. saves time.

I'm with Inject-Dude on that one. People are always going to find something to complain about. If you're happy with your results, that's all that matters.

I barely noticed any changes in my face to start with. I began in July and around October, I'd only dropped maybe 20lbs. Then I hit a higher dose and was sick for a day each week. Stayed there for a few months. The weight came off quickly. Stopped getting sick and kept losing at an even higher...

Yeah, it sounds like they sent you pre-filled syringes, but with a lower dose in each one. So each syringe might have, like, 0.5mg or 1mg, instead of your full weekly dose. You NEED to find the concentration, it's usually listed as mg/ml. Then figure out how many ml you need to get your...

Oh man, I totally get that feeling of excitement turning into 'wait, what?' It sounds like you probably got a lower concentration, so you'll need multiple syringes per dose. The 5ml probably means it's diluted. You REALLY need to find the concentration, like '2.5mg/ml' listed somewhere. Contact...

I've read it has a synergistic effect with TRT, helps with stubborn fat loss.

I also started in October. My Reta titration was like the trials, starting at 2 and increasing by 2 every 4 weeks. Also, exercise is super important. I noticed my subq fat was going down, but not my visceral. I added 2mg of tesa per day before bed. I hear it's the most active of the morelins. My...

There's no understating the positive effects on overall health that come along with the weight loss! I think it's awesome what these medications can do for people managing their type 2 diabetes.

You look amazing and you're doing so well! Don't give up.

Welcome to the community, and congratulations. Before we delve further into this discussion, I'd like to remind everyone of our established guidelines. We do not allow discussions centered around non-FDA approved versions of semaglutide, and explicitly prohibit the sale or solicitation of any...

Thanks everyone for the advice! I think I'm leaning towards smaller increases based on what PlateauCrusher and Nikki_92 mentioned. And thanks for the link Nikki_92 - I'll check it out!

I'm so glad you mentioned checking that! It looks like it's actually 35mg. So I'll need to adjust the bac water accordingly. That means I potentially have seven 5mg doses!