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From what I've read in the trial data, solubility maxes out at different points depending on which one you're using. Tirzepatide tops out around 30mg per ml, reta comes in lower at 24. That's just basic chemistry of how these powders mix, nothing fancy. Matters if you're trying to mix really...

Yeah, looking back, it was too much. Maybe I should cut back to .25 next injection.

I first started at 0.25 and nothing happened. 0.5 is already better. I walked into the grocery store and didn’t need anything. I had to force myself to buy watermelon. Watermelon is the only thing that looks good. Hope you get better soon !!! maybe lower to .25.

Doc put me on a 0.5 dose right off the bat. I did the injection about six hours ago, and I'm regretting it BIG TIME. I've been throwing up non-stop for the last three hours. There's nothing left in my stomach. I get a little relief for a few minutes, but then the nausea slowly creeps back until...

It's interesting how these meds affect everyone differently. I was reading an article where Dr. Mark Moyad was asking Dr. Mark Scholz about semaglutide. Sounds like some people have very minimal side effects, while others really struggle. I wonder if it's just genetics or something else at play.

Being super cold is a known side effect that's not fun. I've always been someone that's warm most of the time. Now I have to wear fuzzy socks and a flannel shirt over my PJs to sleep. I also keep a fleece throw at my recliner, along with a fleece shawl and a heating pad. I've been on the...

Get yourself an electric blanket! Sweaters, wool socks, and even gloves can help too.

Just wanted to chime in on the plateau discussion. It's super common, and there are a few things you can tweak. Like New_Pal mentioned, strength training is HUGE. Also, make sure you're recalculating your TDEE every 10 pounds or so, because your calorie needs will change as you lose weight. And...

That's interesting, BoldCake. The mechanism of action is similar, but tirzepatide also acts on GIP receptors. It might be worth looking into studies comparing the two if your friend is concerned about side effects. I believe there's a lot of individual variability in how people respond to these...

I'm a weekly weigher too! I've found that logging those random weigh-ins can be misleading. Sometimes the scale goes down mid-week, but then my official weigh-in is higher. So now I don't log it. It's more useful as a way to check my habits during the week, knowing that hydration and exercise...

Fantastic progress! Are you a tall person?

Congratulations on your impressive journey!

I always believed in CICO because that's what I heard from doctors and nutritionists. It's confusing with so much conflicting info. Obesity rates show something's not working (genes, cost, upbringing, and marketing play a role too). I've been eating one meal a day with a small snack, trying to...

Congrats on Onderland Dose_Progress131! That's awesome!

Looking good!

Thanks, everyone! It's definitely motivating to hear the encouragement. I'm also a bit nervous about maintenance once I get closer to my goal. Has anyone had experience with that?

HW: 253.6 CW: 232.4 GW: 155 I figured it would be a substantial amount of weight before I really noticed a change in my appearance, much less anyone else pointing it out. I tend to wear clothes that are a bit too big for me anyway. But today, someone at work stopped me and asked if I'd been...

Just saw this. Yes, I incorporated more fruits and protein and scaled back on the carbs and sugary drinks. I also try to walk 30 minutes most days.

Thanks! Do you mean me? I haven't thought about stopping the medication yet. I still have another 30-40 pounds I would like to lose.

I started on Byetta way back in spring of '22 after my blood sugar numbers were too high, without a lot of success, so my doctor put me on Ozempic in August. Since then, I've gotten rid of 106 pounds. My A1C is great, and I feel a million times better. Even with some not-so-great side effects...