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Week one changes are real - the appetite signal shift happens earlier than most expect, and quieter food thoughts are usually the first thing people notice. The smaller portions without effort follow as satiety cues recalibrate. For most, it does keep getting better through the first few months...

Satiety hitting day one with Orforglipron is consistent with early trial data - oral GLP-1 peaks faster than subcutaneous because it skips the absorption delay. Running it alongside an injection means dual GLP-1 stimulation, so watching for amplified GI sides is worth tracking.

Using Reta to get back to a climbing-performance weight rather than a cosmetic target is one of the more specific and measurable goal structures - the functional milestone of matching a previous performance weight is usually a more reliable endpoint than a number derived from a BMI table. The...

I'm taking a similar med, and I noticed yesterday that my under-face area looks trimmer. I think we just look at our faces more than our bodies, so it's easier to spot the changes.

My face slimming down motivated me to get my skincare routine back on track.

Incredible! I've been off for several months, and it's difficult. Have a solid plan for when you stop taking it. You've made huge progress, and it's evident in your appearance. Hold onto that feeling! I'm thinking about going back on a small dose just for upkeep because it seems impossible...

Can you share some of your experience? I need some guidance. Also, congrats on the weight loss!

Awesome! You must be feeling fantastic. Congrats!

How incredible!!! I'm also shedding pounds and going to the gym more. It is mind-blowing to be able to see my muscles.

I'm curious because you mentioned increasing your dosage as winter approached due to your RA. I've been taking weight-loss meds since March '24 and have dropped 162 lbs, reaching my goal weight of 116. However, as I reduce my dosage, I've noticed a severe RA flare-up, which is likely also due to...

I just got an email saying they're up and running again. Orders are delayed a week or so. Hopefully that's all!

I didn't have much to begin with, and after losing thirty pounds, they are just skins now...

Yeah, seconding this! Any tips for minimizing loose skin as you lose? I'm worried about that.

I see the muscle definition too, that's awesome!

I still have a good amount left now, but my husband had something similar happen a few years ago. He got severely constipated and stopped eating much. I didn't notice at first because we were both so busy, but one day I saw he had almost no butt at all. He didn't mention the constipation, just...

I've shed quite a bit too, maybe around 25 pounds. I can only imagine how uncomfortable a long flight will be next month...

Many thanks

Great work, great effort. You're killing it!!!!

That's awesome to hear, HawkGal! Glad to hear your aches are gone - I feel ya on that one, lol.

Thanks everyone.