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The wave pattern is common - suppression builds across weeks rather than staying flat, and PCOS insulin sensitivity makes the variation more pronounced.

Supplement timing matters more than most people realize on these meds - the reduced intake means you're working with a compressed window to get micronutrients in, and taking them with what little you do eat rather than on an empty stomach makes a real difference for absorption and GI tolerance.

Tirz mental health varies - GIP receptor activity is one proposed reason. The sema switch is a legitimate test.

For anyone struggling with cravings, Allen Carr’s book, “Easy Way to Quit Binge Eating,” has been extremely helpful for me on this journey. I highly recommend it!

Good Job. That takes focus and commitment.

That's an incredible transformation! Well done.

I know what you mean about waking up hungry, MaintenanceMode! I often wake up at 3am with a serious hunger pang, no matter how much I eat for dinner. I saw someone say a spoonful of honey helps. I might try that.

That's amazing Metabolic_Mandy! I am also a slow and steady type. It is hard to watch others have faster results, but I am trying to focus on good habits that I can maintain for the long term.

The healthy loss rate is about 0.5-1.0% per week. I prefer to consider a four week average as the loss isn't a straight line - notably if you are a hormonally active woman. I personally gain one week, and lose the next. I began around 275 lbs, which meant I could safely lose 10 lbs my first...

Yay this is great!

Amazing! Thanks for the inspiration 💜

I've been on this journey for a little while now, and it's amazing how much even a small change can make. I've dropped nearly 20 pounds since late summer. I feel fantastic and don't even need my blood pressure meds anymore!

Well done, congratulations on your success!

Awesome progress, wishing you a fantastic 2026!

Wow, congrats on your progress too! It is a wild ride, isn't it? I'm about 5'7".

Thanks! And lol, love the tats! How tall are you? You look great, girl! Way to go everyone!

OMG you guys!!! I actually just reached my target weight. I'm so happy I could cry. The before pic is from like, I dunno, maybe 5 years ago? I was probably at my heaviest then: like 290 lbs. And now, today, I officially weighed in at 175 lbs! *happy tears* I started Mounjaro back in March...

Yeah, I agree with Val_86 - the no carbs thing is key. Carbs before bedtime will blunt the sermorelin.

I find a peptide calculator is super helpful for figuring this out. Check this one out: http://peptidecalculator.com/calculator.php It does all the math for you!

I need it for my diabetes, so I don't care who knows or what they think. If using this medication is "cheating", then so is using any other medicine to improve your health.