I personally think of the fourth compound as more of a metabolic treatment. Started it following a cardiac scare tied to metabolic syndrome. Excess weight was really just the visible symptom of elevated cholesterol, borderline blood sugar, and rising blood pressure. Pretty confident I also had insulin resistance even though it was never formally tested. All of that's resolved now, so this medication genuinely treats my underlying metabolic condition. As a bonus, I've dropped over 100 lbs and move around so much easier.