Ozempic's losing its...oomph?

[ThinQuest928]

Here's something interesting... a recent study showed that over half of people who stopped taking a similar medication for a year actually kept the weight off, and a third even lost *more*! https://www.epicresearch.org/articl...ar-after-stopping-semaglutide-and-liraglutide

 

[thyme_onpath]

the variability in ozempic response between people is real and it goes in both directions. some people hit a ceiling at 1mg and some are just starting to respond at that level. if 30 lbs happened before the plateau hit, the dose question is worth having with your doctor before assuming the medication just stopped working.

 

[peanutwanderer84]

Zero effect at 1mg for 3 months with consistent gym and diet in place is a non-responder pattern on semaglutide. Stopping makes sense rather than pushing higher when the baseline response is not there. The OP plateau at 1mg is a different situation - 30 lbs means the medication was working, the question is whether the dose needs to move or the approach does.

 

[Bobby_97]

6 months on Ozempic with minimal weight loss going to highest dose and then trying Mounjaro is exactly the right call when lipedema is part of the picture. The GLP-1 mechanism does not work the same on lipedema fat tissue and tirz at least adds the GIP angle. Hope the Mounjaro delivers something the Ozempic did not.

 

[thyme_simmerer]

On 1mg ozempic myself, helped me gradually shed 35 pounds, but I've been parked at the exact same weight for the last 6 months with nothing budging. Worth just trying 1.7 and 2.4 wegovy first, same active ingredient as ozempic, less costly than mounjaro, plus you already know your body responds to it.

 

[Kelly14]

On 1mg here too and it's just not doing anything for me anymore. Sadly that's the highest dose available where I live. Never really got nauseous or lost my appetite much on Ozempic in the first place, but now it's completely stalled out. Lost 20kg so far, still need another 15 to hit my ideal weight. So frustrated right now.

 

[reclaimingme1]

Might be worth trying something like Monjaro instead. For plenty of people, Ozempic just doesn't deliver. Right now you're basically burning time and money without progress.

Barely lost anything myself on Ozempic.

 

[dozydabbler]

Made the switch not long ago. No real side effects aside from occasional mild nausea. One thing I did notice is the shot itself stings, which Ozempic never did. Curious if it's holding up as well as Ozempic did for you? Just moved up to .5mg after being on .25. Loss has slowed the last couple weeks for me - actually gained one week, then only an ounce down this week.

 

[mint_stacker]

stayed on the starting dose for the first few months since it worked so well controlling appetite. stopped binging entirely and ate way less, but the scale just wasn't moving. bumped up a level and the weight started dropping fast. but a while into that dose, effectiveness seemed to fade. portions are still way smaller than before starting this, but progress has stalled and there's still a good chunk left i want gone. got my doctor to approve moving up again recently, though a couple doses at the current level still need using up first. even if tolerance keeps building, so long as food noise stays out of the driver's seat, that's honestly enough for me

 

[picklejogger]

Sounds like time to go up if 1mg has stopped working. 1mg lasted me 8 weeks and I stalled near week 6, moved to 1.5 and the weight started coming off again.

 

[Protein-Queen]

A little more than a year with Ozempic, at 1mg. There was a slight stall, then it picked up again and the weight is dropping, plus I can manage side effects better now. Staying on 1mg until I reach goal, then I drop to 0.25mg. Thats my experience anyway.

 

[espresso_doodler6643]

Which parts of your eating did you adjust? That's the mechanism behind losing weight. Ozempic simplifies things, though eating less remains necessary.

 

[date-maintaining66]

depends what you mean by maintenance but late 2023, once i dropped to 75kg from 145, i held between 75 and 83 for a year. not bad given my start, even if still a touch over. took a strict diet to keep hunger and binge risk down, and i stayed hungry constantly. next year i picked up low dose ozempic since prescription made it affordable, roughly $145 monthly for 1mg weekly. nauseous and miserable even on tiny microdoses, but beat nonstop hunger. by 2025 found a cheaper route and switched to tirz, barely any trouble even at 15mg, still a touch hungry so layered in reta too. currently juggling reta 6-8mg, cagri 0.5, tirz 15 for over a year, lost another 13kg down to 64, now at 67. far more tolerable than low dose ozempic, close to eating when hungry without gaining.

 

[downsize_vibes]

Yeah it fades with time... the real trick is actually overhauling how you eat while the appetite suppression still has your back. I coasted for a year just leaning on not being hungry, still eating plenty of junk, just smaller amounts of it. Twenty years of yo-yo dieting left me exhausted, so thinking hard about any of it felt impossible. Over a year on this now, and the past handful of months haven't carried nearly the same punch. Bumped from 0.5 up to 1mg right as the month kicked off and honestly noticed nothing. Put ten pounds back on recently and I'm genuinely scared I'm headed right back to square one.

 

[salty_lateadopter51]

i'm maintaining at the 1mg mark myself. tried bumping to 1.5 once, paying the extra portion out of pocket, but it changed nothing for my hunger levels, and that wasn't worth $300 out of pocket over three months, so i went right back down to 1mg.