Recent content by Leslie40

I'm in Canada too, also paying entirely out of pocket, so I really relate to this. Just made the switch to tirzepatide myself after losing 54 pounds on semaglutide. Were the roles reversed, semaglutide's where I'd begin. Nothing stops you from switching to tirzepatide later if results don't...

Sheesh! Absolutely remarkable change here! Nicely done, genuinely impressive outcome, you've earned every bit of pride and then some. Congrats, looking fantastic and I'm sure it shows in how you feel too! Just wow, all around!

Completely relate to this. Dealt with my very first bad gout episode a few years ago. Genuinely agonizing, the kind of pain that made drastic thoughts cross my mind out of sheer misery. My wife, a practical nurse who doesn't mess around, had me stretched out on my back, leg propped straight up...

Thank you all so much for the responses and reactions, I've reread every one of them more than once. Can't reply to each person individually, but I'm genuinely soaking in the shared sense of humanity running through this whole thread. Keep them coming, please. Also, appreciate everyone who said...

Had rapid weight loss initially, dropping close to half my starting weight. Been on mounjaro roughly three years now. Despite staying on a strong dose, gained back a meaningful chunk over the past year. Just can't seem to budge regardless of what gets tried. Sixty-two years old, average height...

Four years of consistent loss versus the expectation that it should happen in months is one of the healthiest framings in this space - slow enough to actually adapt both physically and psychologically is the approach that sticks.

50 lbs from December and 4 from goal at 8mg is such a clean progression. The slow build from 2mg was worth it to know how your body handles each level. Almost at 180 is so close - what's next for you after hitting goal?

8-10 minutes rolling is on the long end but not unusual - Reta can be more stubborn to dissolve than sema especially if dried slightly. Keep it at room temp before reconstitution and roll gently rather than shake; most batches come together with patience.

The non-GLP landscape has a few well-evidenced options - BPC-157 for tissue repair, TB-500 for recovery. Evidence quality varies; GLP-1s have the most robust outcome data of any of them.

CagriSema's amylin component is worth considering if GLP-1 alone isn't holding appetite the way you need. That said, appetite returning in the first 4-6 weeks after a dose increase is normal settling - not a sign the drug stopped working. Dose bump first is the lower-risk test before switching...

I'm on Biomed and KS-Tec vials. Sent a sample to the lab even after filling them myself and got clean results—no sterility or endotoxin flags. But honestly, you don't need to transfer your BAC into smaller vials. Just grab a sterile 100ml bottle, add benzyl alcohol, and you're done. Yeah, you'll...

Side effects hit different for everyone — we mostly hear the negative because people vent. I haven't had rough symptoms. Maybe a bit queasy a few hours post-shot but food clears it. Clean eating and tons of water help. No hunger ever, but I stick to macros with small portions, protein shakes...

love hearing these stories when you have tons to lose. congratulations!

from a pharmacology angle, that logic doesn't line up with how receptor regulation works. people usually take breaks to let receptors reset and skip the tolerance thing - sometimes eight weeks off, then restart at even a lower dose. otherwise you max out and stop responding.

I'm at 5 right now and down 20 lbs. taking it for blood sugar mostly, not just weight. tried 7.5 before and felt sick constantly. then got covid and the flu on top of that - rough. managing way better on 5. heard there's a plateau around 7.5. wondering if anyone's stayed at 5 and still seen good...