Recent content by TrueCrew

There's actual research showing that cycling treatment on and off leads to reduced effectiveness over time. So this whole detox concept doesn't seem like a great idea from my perspective.

24kg at 5mg over 8 months and still eating normally just in smaller portions is the version of the story that doesn't involve severe food restriction. The OP at 60 lbs in a year from 215 is the same picture scaled up. Natural hunger returning in a manageable way is actually the sign the dose is...

Prescription Ozempic doing nothing except constipation while Tirz worked completely differently is the dual-mechanism story in action. The OP stopping and restarting is a different situation from a non-responder from the start. Were there any other changes between stopping and restarting that...

the long-restart timeline after a year off is a documented pattern in community experience - the first 6-8 weeks back on the medication can look like the drug is not working when the pharmacokinetics are actually building back up to the therapeutic level. the weight regain that happened during...

3 weeks at a plateau with nothing changing in diet or exercise is frustrating but not unusual after a switch. The full reta effect sometimes takes a month to show up on the scale. What dose are you at and is the appetite side doing anything even if the scale isn't?

Limiting the stash to what you'll actually use is the rational calculation when degradation data is your primary concern. The compounded tirz question for the OP is different from the stash-vs-use question but the underlying logic of knowing your product is reliable runs through both.

10 pounds the first month on sema is solid - you had 20. Numbers don't lie. Keep it going.

Tirz for GIP and sema for GLP-1 as complementary rather than redundant is the mechanism argument for keeping the stack rather than switching. The OP's year success on sema alone suggests it's still doing its job. Adding tirz for the GIP angle is a different calculation than switching to tirz -...

Ha - that's a very specific perspective on the current situation. The 93kg milestone deserves celebrating regardless of household circumstances.

The Metformin add-on at plateau is a well-supported combination - it works through a different mechanism than GLP-1 and the two together produce more sustained results than either alone for people managing T2D alongside weight loss. Your doctor is using the evidence-based playbook.

Anhedonia at 4.5mg/week that didn't improve is the experience that makes people stop at target rather than push higher. Hitting goal on that dose and then getting off it resolving the mood issue is the best outcome in that situation. Worth flagging for anyone planning the higher dose range - the...

The per pound vs per kilogram translation error is probably responsible for a huge chunk of influencer protein advice. 1.6-2.2g/lb would have people eating almost 3x the evidence-based target. Getting that number right actually matters for people running deficits on GLP-1s.

94.5 to 76.4 with 75 as the target means you're essentially there. Staying at the low dose and letting it work at its own pace while almost at goal is a disciplined approach. Almost done.

The local versus systemic delivery distinction is worth keeping in mind - BPC's mechanism for acute injury benefits from proximity to the target tissue, while TB-500's systemic action doesn't require site targeting. A blend means you're not optimizing for either mechanism simultaneously.

Six weeks at 0.4mg with that side effect profile is a slow titration - most nausea resolves when the dose has stabilized for 3-4 weeks at a given level.