Oral tirzepatide: Real deal or not?

SnackGirl

SnackGirl

Active member
I'm seeing some companies pushing oral tirzepatide instead of the usual shots. Some folks are immediately calling it a scam and saying the providers are ruining their reputation.

I did a quick search and found:
* Peptides in pill form are tricky because the GI tract breaks them down.
* But there's an oral semaglutide tablet approved for treating diabetes. Studies show it's not quite as effective for weight loss as the injectable version, but still better than liraglutide. It's just as good for diabetes though.
* Oral sema is dosed at 14mg/day compared to 0.5mg/week in shot form. So, it seems like they're giving you a much larger dose and hoping a small percentage survives the GI tract and works like a shot.
* I saw a company rep mention their oral tirzepatide is sublingual, so it absorbs in the mouth instead of the stomach.

So, is oral tirzepatide a total scam, or is it just an experimental form of the drug that needs more research to prove it works as well as the injections?

I'm good on tirz for a while, but I'm wondering if these telehealth providers are pulling a fast one, or if a sublingual or high-dose tablet form of tirz might actually be effective.
 
It's a total scam. If it was legit, Lilly would be all over it. This is just a shady way for telehealth and compounding pharmacies to make money. I'd like to see some actual data showing proper absorption levels.

Rybelsus only works 'cause it has a special delivery system that releases it at the right spot in your gut.
 
I'm with @almost-there, it's most likely a scam. I used Rybelsus, and it worked, but you had to take it very specifically - empty stomach, tiny bit of water, same time every day.

I doubt these telehealth companies have copied that delivery system. Some claim sublingual absorption, but I don't think it works well. I've seen videos saying it *might* work with a very high dose to compensate for losses. I don't think these companies want to shell out for that high of a dose.
 
I don't think cost is the issue, really. They can get good prices if they buy in bulk and mark things up a lot. But they should be careful about using super high doses without knowing the side effects.
 
The oral tirz that's being sold right now seems to be in dissolvable tablets at low doses, like 3mg or 6mg, taken daily.

No high-dose pill yet that you can grind into subq... but that's a clever idea. Wonder if it's possible with rybelsus/sema oral. A 14mg tablet could be a few weeks' worth of 2.4mg subq.
 
I doubt half the people wanting oral tirz could even follow the directions. They'll just be dumb enough to believe the marketing and fake reviews. Who's even making this stuff? The irony, considering what I keep in my freezer.
 
Just some thoughts: A lot of people seem to be saying they've been using sublingual Tirzepatide for months with good results. Most of these places sell it alongside the regular shots, so if it was totally fake, you'd expect bad reviews that would hurt their business--the sublingual is usually a bit cheaper, which doesn't make sense to me. Also, Novo Nordisk is testing an oral/sublingual form of Semaglutide, so it's possible to do something similar with Tirzepitide.
 
I saw a recent post on a semaglutide subreddit from someone who switched from injectable Wegovy to the pill form. They said they were really worried about losing their progress, but their doctor explained the oral absorption process. They've been logging their meals and haven't noticed a huge difference, so it seems like it can work for some people!
 
SteadyOnSema said:
I saw a recent post on a semaglutide subreddit from someone who switched from injectable Wegovy to the pill form. They said they were really worried about losing their progress, but their doctor explained the oral absorption process. They've been logging their meals and haven't noticed a huge difference, so it seems like it can work for some people!
Click to expand...

I'm skeptical. A lot of those posts sound like they're written by AI. Plus, the user said they liked the 30-minute fasting window for circadian rhythm benefits... seems a little sus.
 
It looks like there are some interesting studies coming out about GLP-1 pills and other ways to treat obesity besides just injections. It could open up new avenues for people who don't like needles or have other issues. We need more options!
 
The stubborn belly is real. I've dropped 26 down from 215 but that fat around the middle won't budge. Want to hit 170, maybe 165. Probably just how it goes at this age without serious core work.
 
What baseline tests do you all recommend before starting? I tell everyone asking about GLP weight loss to get bloodwork before and during. Here's my list: CMP, lipase, amylase, thyroid panel, HbA1c, fasting glucose, lipid panel plus ApoB, and hs-CRP. Anything to add?
 
Bipolar here too. Felt some of the same stuff, especially the compulsive side. Treated bipolar with some control before, but this med really helped pull the compulsion back.
 
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