Reta plateau at week 10 - dose up?

Ten weeks with 30 lbs down and a two-week stall is not a plateau - the curve resumes. Data pattern at this stage is normal.

A brutal first week like that is exactly why people need to stick with it - once you get past the initial phase the body adapts and it becomes sustainable. 20 lbs from 1mg with minimal muscle loss is a good early number. What dose are you on now and what's the trajectory been?

The rule-of-thumb is a rough guide - 'stay if losing' makes sense, but 'stay anyway if side effects' even without loss deserves a closer look. If side effects are at the level they're affecting quality of life and the scale isn't moving, holding through that combination longer doesn't serve either goal.