Day 6 at 0.5mg is very early - the suppression effect for reta typically starts showing more clearly around week 2-3 at that dose. The nausea you felt this morning is actually a signal it's working. Craving pizza at day 6 doesn't mean it's not working - the full appetite change takes longer to establish. Splitting doses early like you did can extend the side effect window, so it's worth giving a consistent dose schedule a few weeks before adjusting.