Restarting GLP-1s: My bad experience

55 and post-menopausal and hitting exactly the target in about a year is a genuinely good result - the hormonal context at that stage typically makes loss harder and slower. The carefully titrated approach at a high dose without significant problems is good data for people who worry the medication won't work in that demographic.

The 3-week break without dose adjustment before restart is the specific cause of the 28-hour vomiting episode - the body had begun losing its adaptation and the full previous dose hit without the tolerance that had built up. The rule for any break longer than 10-14 days is to drop back at least one dose level for the restart.