Restarting GLP-1s: My bad experience

Hong Kong Yanpep International
55 and post-menopausal and hitting exactly the target in about a year is a genuinely good result - the hormonal context at that stage typically makes loss harder and slower. The carefully titrated approach at a high dose without significant problems is good data for people who worry the medication won't work in that demographic.
 
The 3-week break without dose adjustment before restart is the specific cause of the 28-hour vomiting episode - the body had begun losing its adaptation and the full previous dose hit without the tolerance that had built up. The rule for any break longer than 10-14 days is to drop back at least one dose level for the restart.
 
Lost forty pounds on a certain compound a couple years back. Stopped due to pregnancy. Currently on a small amount now and results are finally beginning to show again. Side effects seem noticeably milder this time too.
 
If it helps at all, I lost some weight early on then plateaued for nine months straight. Maxed out sema first, then switched to triz and worked my way toward its ceiling too, zero pounds to show for that climb. Feels important to share stories like mine since most posts are the 'been on sema six minutes and already down 15lbs' type. Doesn't paint an honest picture of what most of us actually go through. The whole thing is a painfully slow grind, and depending on your body you might end up losing it all, part of it, or nothing. Don't quit. I haven't.
 
Exactly what happened to me. Things went smoothly until my amount increased, then I got hit with awful stomach pain, gastritis or something similar. Bad enough that I went through bloodwork and testing, convinced it was Crohn's or gallbladder trouble. Stopped taking it. Weight crept back on and now I'm restarting Sema, currently on my second shot. Planning to be far more cautious raising the amount this time. Anyone with tips, please share. And OP, you're looking fantastic by the way.
 
Curious about this myself. Dropped about 80 pounds across eighteen months on the lower sema doses, then stopped back in January. Put roughly 10 back on over these past several months, and I'm considering restarting it since it worked so well the first go-round.
 
Nobody knows yet, for GLPs or amylin agonists. One rodent study found semaglutide got weaker after repeated stopping and starting, when the animals were allowed to regain on fatty food during the breaks. That's the only real evidence, apart from scattered online stories of people finding GLPs weaker after a restart (though that is often just because they already lost weight). Nobody has repeated that rodent study or tested it in people, yet the result was pretty strong and unsettling, so I'd hesitate before going on and off. Amylin agonists such as cargi have no research whatsoever yet.
 
This could be the cause. That 'getting used to' feeling could even be good, it suggests the drug does something. I haven't seen evidence that people build tolerance, and lots reduce during maintenance. The real problem seems to be stopping and restarting, which affects GLP1 efficacy. If you only reached 12mg Tirz it makes sense to titrate higher. Early trials topped out at 15mg, and now 25mg+ is under study. I don't know your starting point, your total loss or the timeline, but on the surface titrating up looks like your best bet, and if needed stacking sema in a tiny amount (some have had success). For my part I stuck to the protocol and reached goal weight after roughly 27% loss in 7 months.
 
Is it possible the dose is off, or that the batch is wrong? Unpopular truth: a few compounding pharmacies ship products with wrong labels or wrong doses. Asking only because some folks source from friends. With symptoms like these, stop immediately and see your doctor. That's exactly why medical oversight matters. A doctor could switch you to something else, for example semaglutide, available as an injection or a pill. Six weeks of these awful symptoms sounds exhausting, and you've probably dropped a lot of weight, mostly water. Nobody can be their own doctor, and online forums aren't doctors either. Drugs this potent call for monitoring.
 
I did well on Sema for a while, until my employer dropped weight loss coverage. I dosed every other week for 3 months, and it took another month to line up a new supply. Restarting at the lowest dose gave me only 6 lbs across 4 months, and 4 of those came after adding low dose cagri in December. Some weeks later a study confirmed higher doses work. Annoying timing, yet Tirz had already won me over, and I hoard so much now that it could outlive me. LOL My cousin does what you do. Before retiring she stocked up, and her last pens expire soon. She worries about efficacy, so I calmed her fears about the cost once the pens run out.
 
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